Evidence map›Paper›PMID 26611548›Full record

ReviewRheumatic diseases clinics of North America2016

Corticosteroids: Mechanisms of Action in Health and Disease.

Sivapriya Ramamoorthy, John A Cidlowski

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Rheumatic diseases clinics of North America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 337 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
337citing papers in PubMed, 8 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

337 citing papers in PubMed, 8 syntheses or guidelines pooled it, 651 citations in OpenAlex.

  1. Pooled it
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  4. Corticosteroid therapy for nephrotic syndrome in children.The Cochrane database of systematic reviews · 2024
    Pooled it
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  9. Trial
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277 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sivapriya RamamoorthySignal Transduction Laboratory, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangular Park, 111 T. W. Alexander Drive, NC 27709, USA.
John A CidlowskiSignal Transduction Laboratory, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangular Park, 111 T. W. Alexander Drive, NC 27709, USA. Electronic address: cidlows1@niehs.nih.gov.
National Institute of Environmental Health Sciences · US

Funding

Glucocorticoid Hormone ActionZIAES090057 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CIDLOWSKI, JOHN A. · 2009 to 2025
$44.9M
ApoptosisZIAES090079 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CIDLOWSKI, JOHN A. · 2009 to 2022
$12.8M
Intramural NIH HHS Z99 ES999999
6 · The paper itself

Abstract

Glucocorticoids are primary stress hormones that regulate a variety of physiologic processes and are essential for life. The actions of glucocorticoids are predominantly mediated through the classic glucocorticoid receptor (GR). GRs are expressed throughout the body, but there is considerable heterogeneity in glucocorticoid sensitivity and biologic responses across tissues. The conventional belief that glucocorticoids act through a single GR protein has changed dramatically with the discovery of a diverse collection of receptor isoforms. This article provides an overview of the molecular mechanisms that regulate glucocorticoid actions, highlights the dynamic nature of hormone signaling, and discusses the molecular properties of the GR isoforms.

Indexed as

Adrenal Cortex HormonesGene Expression RegulationGlucocorticoidsHumansHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemPolymorphism, GeneticProtein IsoformsProtein Processing, Post-TranslationalReceptors, GlucocorticoidSignal TransductionAdrenal Cortex HormonesGlucocorticoidsProtein IsoformsReceptors, GlucocorticoidGlucocorticoidGlucocorticoid receptorGlucocorticoid signalingHypothalamic-pituitary-adrenal axisIsoformsPhosphorylationPolymorphism

Identifiers

PMID26611548
PMCPMC4662771
OpenAlexW2180085345

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.