Evidence map›Paper›PMID 26611535›Full record

ArticleClinical and experimental nephrology2016

Extracellular volume expansion and the preservation of residual renal function in Korean peritoneal dialysis patients: a long-term follow up study.

Harin Rhee, Min Ja Baek, Hyun Chul Chung, Jong Man Park, Woo Jin Jung, Soo Min Park, Jang Won Lee, Min Ji Shin, Il Young Kim, Sang Heon Song and 4 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Clinical and experimental nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Observational
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Harin RheeDepartment of Internal Medicine, Pusan National University School of Medicine, Pusan, South Korea.
Min Ja BaekDepartment of Nursing Service, Pusan National University School of Medicine, Pusan, South Korea.
Hyun Chul ChungDepartment of Internal Medicine, Ulsan University Hospital, Ulsan, South Korea.
Jong Man ParkDepartment of Internal Medicine, Pusan National University School of Medicine, Pusan, South Korea.
Woo Jin JungDepartment of Internal Medicine, Pusan National University School of Medicine, Pusan, South Korea.
Soo Min ParkDepartment of Internal Medicine, Pusan National University School of Medicine, Pusan, South Korea.
Jang Won LeeDepartment of Internal Medicine, Pusan National University School of Medicine, Pusan, South Korea.
Min Ji ShinDepartment of Internal Medicine, Pusan National University School of Medicine, Pusan, South Korea.
Il Young KimDepartment of Internal Medicine, Pusan National University School of Medicine, Pusan, South Korea.
Sang Heon SongDepartment of Internal Medicine, Pusan National University School of Medicine, Pusan, South Korea.
Dong Won LeeDepartment of Internal Medicine, Pusan National University School of Medicine, Pusan, South Korea.
Soo Bong LeeDepartment of Internal Medicine, Pusan National University School of Medicine, Pusan, South Korea.
Ihm Soo KwakDepartment of Internal Medicine, Pusan National University School of Medicine, Pusan, South Korea.
Eun Young SeongDepartment of Internal Medicine, Pusan National University School of Medicine, Pusan, South Korea. sey-0220@hanmail.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn chronic peritoneal dialysis patients, preservation of residual renal function (RRF) is a major determinant of patient survival, and maintaining sufficient intravascular volume has been hypothesized to be beneficial for the preservation of RRF. The present study aimed to test this hypothesis using multifrequency bioimpedence analyzer (MFBIA), in Korean peritoneal dialysis patients.

methodsA total of 129 patients were enrolled in this study. The baseline MFBIA was checked, and the patients were divided into the following two groups: group 1, extracellular water per total body water (ECW/TBW) < median, group 2, ECW/TBW > median. We followed up the patients, and then we analyzed the changes in the urine output (UO) and the solute clearance (weekly uKt/V) in each group. Data associated with patient and technical survivor were collected by medical chart review. The volume measurement was made using Inbody S20 equipment (Biospace, Seoul, Korea). We excluded the anuric patients at baseline.

resultThe median value of ECW/TBW was 0.396. The mean patient age was 49.74 ± 10.01 years, and 62.1 % of the patients were male; most of the patients were on continuous ambulatory peritoneal dialysis (89.1 %). The mean dialysis vintage was 26.20 ± 28.71 months. All of the patients were prescribed hypertensive medication, and 48.5 % of the patients had diabetes. After 25.47 ± 6.86 months of follow up, ΔUO and Δweekly Kt/V were not significantly different in the two groups as follows: ΔUO (-236.07 ± 185.15 in group 1 vs -212.21 ± 381.14 in group 2, p = 0.756); Δ weekly Kt/v (-0.23 ± 0.43 in group 1 vs -0.29 ± 0.49 in group 2, p = 0.461). The patient and technical survivor rate was inferior in the group 2, and in the multivariable analysis, initial hypervolemia was an independent factor that predicts both of the patient mortality [HR 1.001 (1.001-1.086), p = 0.047] and the technical failure [HR 1.024 (1.001-1.048), p = 0.042].

conclusionsExtracellular volume expansion, measured by MFBIA, does not help preserve residual renal function, and is harmful for the technical and patient survival in Korean peritoneal dialysis patients.

Indexed as

Body CompositionGlomerular Filtration RatePeritoneal DialysisAdultBody WaterChi-Square DistributionElectric ImpedanceFemaleFollow-Up StudiesHumansKaplan-Meier EstimateKidneyKidney DiseasesMaleMiddle AgedMultivariate AnalysisMultifrequency bioimpedance analysisPeritoneal dialysisResidual renal function

Identifiers

PMID26611535

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.