Evidence map›Paper›PMID 26611103›Full record

ArticleNeurobiology of disease2016

HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders.

Jerel Adam Fields, Elisabeth Serger, Sofia Campos, Ajit S Divakaruni, Changyoun Kim, Kendall Smith, Margarita Trejo, Anthony Adame, Brian Spencer, Edward Rockenstein and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. The Essential Role of Mitochondrial Dynamics in Viral Infections.International journal of molecular sciences · 2025
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Jerel Adam FieldsDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Elisabeth SergerDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Sofia CamposDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Ajit S DivakaruniDepartment of Pharmacology, University of California San Diego, La Jolla, CA, USA.
Changyoun KimDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Kendall SmithDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Margarita TrejoDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Anthony AdameDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Brian SpencerDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Edward RockensteinDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Anne N MurphyDepartment of Pharmacology, University of California San Diego, La Jolla, CA, USA.
Ronald J EllisDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Scott LetendreDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Igor GrantDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Eliezer MasliahDepartment of Pathology, University of California San Diego, La Jolla, CA, USA; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA. Electronic address: emasliah@ucsd.edu.
University of California, San Diego · US

Funding

VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALASKO, DOUGLAS R · 1985 to 2018
$55.4M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
California NeuroAIDS Tissue NetworkU24MH100928 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ACHIM, CRISTIAN L, MOORE, DAVID J · 2013 to 2023
$13.9M
Mechanisms of Neuroprotection in HIV EncephalitisR01MH062962 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MASLIAH, ELIEZER · 2002 to 2016
$5.2M
Project-002P30NS076411 · NINDS · SCINTILLON INSTITUTE FOR PHOTOBIOLOGY · PI LIPTON, STUART A · 2011 to 2016
$4.5M
Targeting the mitochondrial pyruvate carrier to treat neurodegenerative diseaseR01NS087611 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, GEOFFREY A, MURPHY, ANNE N. · 2014 to 2018
$2.9M
a-synuclein clearance strategies for the treatment of Lewy body disease.R37AG018440 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MASLIAH, ELIEZER · 2006 to 2014
$2.7M
Clearance Pathways in the CNS in Aging and HIVR01AG043384 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DESPLATS, PAULA ALEJANDRA · 2012 to 2016
$1.9M
Midcareer Investigator Award in Patient-Oriented NeuroAIDS ResearchK24MH097673 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LETENDRE, SCOTT L · 2013 to 2017
$917k
Mechanisms of mitochondrial fission/fusion dysregulation during HIV-1-associatedF32NS083426 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIELDS, JEREL ADAM · 2013 to 2014
$94k
NIA NIH HHS AG043384NIA NIH HHS P50 AG005131NIA NIH HHS R01 AG043384NIA NIH HHS R37 AG018440NIMH NIH HHS K24 MH097673NIMH NIH HHS MH062962NIMH NIH HHS MH100928NIMH NIH HHS MH5974NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH062962NIMH NIH HHS U24 MH100928NINDS NIH HHS 1F32NS083426-01NINDS NIH HHS F32 NS083426NINDS NIH HHS NS087611NINDS NIH HHS P30 NS076411NINDS NIH HHS R01 NS087611
6 · The paper itself

Abstract

HIV-associated neurocognitive disorders (HAND) still occur in approximately 50% of HIV patients, and therapies to combat HAND progression are urgently needed. HIV proteins are released from infected cells and cause neuronal damage, possibly through mitochondrial abnormalities. Altered mitochondrial fission and fusion is implicated in several neurodegenerative disorders. Here, we hypothesized that mitochondrial fission/fusion may be dysregulated in neurons during HAND. We have identified decreased mitochondrial fission protein (dynamin 1-like; DNM1L) in frontal cortex tissues of HAND donors, along with enlarged and elongated mitochondria localized to the soma of damaged neurons. Similar pathology was observed in the brains of GFAP-gp120 tg mice. In vitro, recombinant gp120 decreased total and active DNM1L levels, reduced the level of Mitotracker staining, and increased extracellular acidification rate (ECAR) in primary neurons. DNM1L knockdown enhanced the effects of gp120 as measured by reduced Mitotracker signal in the treated cells. Interestingly, overexpression of DNM1L increased the level of Mitotracker staining in primary rat neurons and reduced neuroinflammation and neurodegeneration in the GFAP-gp120-tg mice. These data suggest that mitochondrial biogenesis dynamics are shifted towards mitochondrial fusion in brains of HAND patients and this may be due to gp120-induced reduction in DNM1L activity. Promoting mitochondrial fission during HIV infection of the CNS may restore mitochondrial biogenesis and prevent neurodegeneration.

Indexed as

Mitochondrial DynamicsAdultAnimalsBrainCognition DisordersDynaminsEncephalitisFemaleFrontal LobeGTP PhosphohydrolasesHIV Envelope Protein gp120HIV InfectionsHumansMaleMiceMicrotubule-Associated ProteinsDNM1L protein, humanDynaminsGTP PhosphohydrolasesHIV Envelope Protein gp120Mfn1 protein, humanMicrotubule-Associated ProteinsMitochondrial Membrane Transport ProteinsMitochondrial ProteinsDNM1LFission/fusiongp120HIVMitochondriaNeurodegeneration

Identifiers

PMID26611103
PMCPMC4713337
OpenAlexW2174707229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.