Evidence map›Paper›PMID 26610921›Full record

ReviewNeurotoxicology2017

Neurotoxicity of traffic-related air pollution.

Lucio G Costa, Toby B Cole, Jacki Coburn, Yu-Chi Chang, Khoi Dao, Pamela J Roqué

Abstract readReview
In one paragraph

Review in Neurotoxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 4 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

176 citing papers in PubMed, 4 syntheses or guidelines pooled it, 393 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Urban PMMolecular neurobiology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Neurobiophilia.Brain sciences · 2026
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Early-life NOThe Lancet regional health. Western Pacific · 2025
    Article

116 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Lucio G CostaDept. of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Dept. of Neuroscience, University of Parma, Italy. Electronic address: lgcosta@u.washington.edu.
Toby B ColeDept. of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Center on Human Development and Disability, University of Washington, Seattle, WA, USA.
Jacki CoburnDept. of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Yu-Chi ChangDept. of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Khoi DaoDept. of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Pamela J RoquéDept. of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
University of Washington · US

Funding

WILDLIFE BIOMARKER APPLICATIONS TO REMEDIATION DECISION MAKINGP42ES004696 · NIEHS · UNIVERSITY OF WASHINGTON · PI GALLAGHER, EVAN P · 1987 to 2021
$51.2M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI ALI SHOJAIE · 1995 to 2026
$42.5M
Environmetal Pathology/Toxicology Training ProgramT32ES007032 · NIEHS · UNIVERSITY OF WASHINGTON · PI FAUSTMAN, ELAINE M, ROSENFELD, MICHAEL E · 1985 to 2023
$10.7M
Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI DOHERTY, DANIEL · 2014 to 2019
$7.9M
Air pollution and the brain: gender as an important determinant of susceptibilityR01ES022949 · NIEHS · UNIVERSITY OF WASHINGTON · PI COSTA, LUCIO G · 2013 to 2017
$1.7M
NICHD NIH HHS U54 HD083091NIEHS NIH HHS P30 ES007033NIEHS NIH HHS P42 ES004696NIEHS NIH HHS R01 ES022949NIEHS NIH HHS T32 ES007032
6 · The paper itself

Abstract

The central nervous system is emerging as an important target for adverse health effects of air pollution, where it may contribute to neurodevelopmental and neurodegenerative disorders. Air pollution comprises several components, including particulate matter (PM) and ultrafine particulate matter (UFPM), gases, organic compounds, and metals. An important source of ambient PM and UFPM is represented by traffic-related air pollution, primarily diesel exhaust (DE). Human epidemiological studies and controlled animal studies have shown that exposure to air pollution, and to traffic-related air pollution or DE in particular, may lead to neurotoxicity. In particular, air pollution is emerging as a possible etiological factor in neurodevelopmental (e.g. autism spectrum disorders) and neurodegenerative (e.g. Alzheimer's disease) disorders. The most prominent effects caused by air pollution in both humans and animals are oxidative stress and neuro-inflammation. Studies in mice acutely exposed to DE (250-300μg/m

Indexed as

AnimalsCytokinesFemaleHippocampusHumansInternational CooperationMaleMalondialdehydeMiceNeurodegenerative DiseasesNeurotoxicity SyndromesOxidative StressParticulate MatterVehicle EmissionsCytokinesMalondialdehydeParticulate MatterVehicle EmissionsDiesel exhaustNeurodegenerative diseasesNeurodevelopmental disordersNeuro-inflammationNeurotoxicityOxidative stressTraffic-related air pollution

Identifiers

PMID26610921
PMCPMC4875879
OpenAlexW2173451380

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.