Evidence map›Paper›PMID 26610916›Full record

ReviewCurrent topics in membranes2015

Cell Receptor-Basement Membrane Interactions in Health and Disease: A Kidney-Centric View.

Corina M Borza, Xiwu Chen, Roy Zent, Ambra Pozzi

Abstract readReview
In one paragraph

Review in Current topics in membranes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
8.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Basement membranes at a glance.Journal of cell science · 2025
    Review
  2. Integrins in the kidney - beyond the matrix.Nature reviews. Nephrology · 2025
    Review
  3. Integrating integrins with the hallmarks of cancer.Matrix biology : journal of the International Society for Matrix Biology · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Extracellular Matrix in Kidney Fibrosis: More Than Just a Scaffold.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019
    Review
  9. Article
  10. Article
  11. Review
  12. Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis.Matrix biology : journal of the International Society for Matrix Biology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Corina M BorzaDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, TN, USA.
Xiwu ChenDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Roy ZentDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Medicine, Veterans Administration Hospital, Nashville, TN, USA.
Ambra PozziDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Medicine, Veterans Administration Hospital, Nashville, TN, USA.
Vanderbilt University Medical Center · US

Funding

The Laminin Receptors in Kidney FibrosisR01DK069921 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ROY ZENT · 2005 to 2026
$9.5M
Betal Integrin and Renal TubulogenesisR01DK075594 · NIDDK · VANDERBILT UNIVERSITY · PI ZENT, ROY · 2008 to 2015
$2.6M
The P450 Epoxygenases as Pro-Oncogenic EnzymesR01CA162433 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI POZZI, AMBRA · 2012 to 2016
$1.9M
Integrin/TGF-beta Axis in Tubulointerstitial FibrosisR01DK095761 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI POZZI, AMBRA · 2013 to 2016
$1.4M
Structure Function Analysis of Integrins alpha1beta1 and alpha2beta2R01DK083187 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SANDERS, CHARLES R, ZENT, ROY · 2010 to 2013
$1.3M
The ILK/PINCH/Parvin complex in renal tubulogenesisI01BX002196 · VA · VETERANS HEALTH ADMINISTRATION · PI ZENT, ROY · 2013 to 2025
–
Role of Collagen Binding Receptors in GlomerulosclerosisI01BX002025 · VA · VETERANS HEALTH ADMINISTRATION · PI AMBRA POZZI · 2013 to 2026
–
BLRD VA I01 BX002025BLRD VA I01 BX002196NCI NIH HHS R01 CA162433NIDDK NIH HHS DK069221NIDDK NIH HHS DK075594NIDDK NIH HHS DK083187NIDDK NIH HHS DK095761NIDDK NIH HHS L40 DK069221NIDDK NIH HHS R01 DK069921NIDDK NIH HHS R01 DK075594NIDDK NIH HHS R01 DK083187NIDDK NIH HHS R01 DK095761
6 · The paper itself

Abstract

Cell-extracellular matrix (ECM) interactions are essential for tissue development, homeostasis, and response to injury. Basement membranes (BMs) are specialized ECMs that separate epithelial or endothelial cells from stromal components and interact with cells via cellular receptors, including integrins and discoidin domain receptors. Disruption of cell-BM interactions due to either injury or genetic defects in either the ECM components or cellular receptors often lead to irreversible tissue injury and loss of organ function. Animal models that lack specific BM components or receptors either globally or in selective tissues have been used to help with our understanding of the molecular mechanisms whereby cell-BM interactions regulate organ function in physiological and pathological conditions. We review recently published works on animal models that explore how cell-BM interactions regulate kidney homeostasis in both health and disease.

Indexed as

AnimalsBasement MembraneEpithelial CellsHumansKidneyKidney DiseasesProtein BindingReceptors, Cell SurfaceReceptors, Cell SurfaceAlport syndromeBasement membraneDiscoidin domain receptorsExtracellular matrixIntegrinsKidneyMouse modelsPeroxidasinPierson syndromeTubular cells

Identifiers

PMID26610916
PMCPMC4913201
OpenAlexW2174426029

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.