ArticleStem cell reports2015
Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.
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Article in Stem cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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37citing papers in PubMed, 1 pooled it
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain imaging genetics in ADHD and beyond - Mapping pathways from gene to disorder at different levels of complexity.Neuroscience and biobehavioral reviews · 2017Pooled it
- Article
- Abnormal synaptic architecture in iPSC-derived neurons from a multi-generational family with genetic Creutzfeldt-Jakob disease.Stem cell reports · 2024Article
- Social epigenomics: are we at an impasse?Epigenomics · 2021Review
- Making Sense of Patient-Derived iPSCs, Transdifferentiated Neurons, Olfactory Neuronal Cells, and Cerebral Organoids as Models for Psychiatric Disorders.The international journal of neuropsychopharmacology · 2021Review
- Integration of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons into Rat Brain Circuits.Bio-protocol · 2020Article
- Human pluripotent stem cell-derived models and drug screening in CNS precision medicine.Annals of the New York Academy of Sciences · 2020Review
- Genetic predispositions of Parkinson's disease revealed in patient-derived brain cells.NPJ Parkinson's disease · 2020Review
- Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses.Cell reports · 2019Article
- Applying Deep Neural Network Analysis to High-Content Image-Based Assays.SLAS discovery : advancing life sciences R & D · 2019Article
- Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders.Antioxidants & redox signaling · 2019Review
- Studying Human Neurological Disorders Using Induced Pluripotent Stem Cells: From 2D Monolayer to 3D Organoid and Blood Brain Barrier Models.Comprehensive physiology · 2019Review
- The effect of rho kinase inhibition on morphological and electrophysiological maturity in iPSC-derived neurons.Cell and tissue research · 2019Article
- Early Actions of Neurotransmitters During Cortex Development and Maturation of Reprogrammed Neurons.Frontiers in synaptic neuroscience · 2019Review
- Cortical interneuron function in autism spectrum condition.Pediatric research · 2019Review
- Human-Monkey Chimeras for Modeling Human Disease: Opportunities and Challenges.Stem cells and development · 2018Review
- Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?Alcoholism, clinical and experimental research · 2018Review
- Understanding the role of steroids in typical and atypical brain development: Advantages of using a "brain in a dish" approach.Journal of neuroendocrinology · 2018Review
- Tulsa 1000: a naturalistic study protocol for multilevel assessment and outcome prediction in a large psychiatric sample.BMJ open · 2018Observational
- The Efficacy of Graphene Foams for Culturing Mesenchymal Stem Cells and Their Differentiation into Dopaminergic Neurons.Stem cells international · 2018Article
Corrections and comments
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Authors and funding
25 authors.
Kristen J BrennandDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.
M Carol MarchettoLaboratory of Genetics, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, San Diego, CA 92037, USA.
Nissim BenvenistyDepartment of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Oliver BrüstleInstitute of Reconstructive Neurobiology, LIFE & BRAIN Center, University of Bonn, Bonn 53127, Germany.
Allison EbertDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Juan Carlos Izpisua BelmonteGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, San Diego, CA 92037, USA.
Ajamete KaykasDepartment of Neurobiology, Novartis Institute for BioMedical Research, Inc., 100 Technology Square, Cambridge, MA 02139, USA.
Madeline A LancasterLaboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
Frederick J LiveseyGurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
Michael J McConnellDepartment of Biochemistry and Molecular Genetics, Center for Brain Immunology and Glia, University of Virginia School of Medicine, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA.
Ronald D McKayBrain Development, Lieber Institute for Brain Development, 855 North Wolfe Street, Baltimore, MD 21205, USA.
Eric M MorrowDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, 70 Ship Street, Providence, RI 02912, USA.
Alysson R MuotriDepartment of Cellular & Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA.
David M PanchisionDevelopmental Neurobiology Program, National Institute of Mental Health, 6001 Executive Boulevard, Bethesda, MD 20892, USA.
Lee L RubinDepartment of Stem Cell and Regenerative Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
Akira SawaDepartment of Psychiatry and Behavioral Sciences, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Frank SoldnerWhitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.
Hongjun SongInstitute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA.
Lorenz StuderStem Cell and Tumor Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 256, New York, NY 10021, USA.
Sally TempleNeural Stem Cell Institute, One Discovery Drive, Rensselaer, NY 12144, USA.
Flora M VaccarinoChild Study Center, Yale University, 230 South Frontage Road, New Haven, CT 06520, USA.
Jun WuGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, San Diego, CA 92037, USA.
Pierre VanderhaeghenInstitute of Interdisciplinary Research (IRIBHM), University of Brussels ULB, 808, Route de Lennik, 1070 Brussels, Belgium.
Fred H GageLaboratory of Genetics, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, San Diego, CA 92037, USA. Electronic address: fgage@salk.edu.
Rudolf JaenischWhitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA. Electronic address: jaenisch@wi.mit.edu.
Funding
Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8MProject 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2020
$19.9MSingle-cell approaches to deconvolution of disease-associated signalsU19MH107367 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CALLAWAY, EDWARD M · 2015 to 2019
$15.0MTranscriptional condensates, epigenetic editing and Rett SyndromeR01MH104610 · NIMH · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI JAENISCH, RUDOLF, YOUNG, RICHARD · 2014 to 2023
$7.4MSmn Regulation of Neuromuscular Morphogenesis in DrosophilaP01NS066888 · NINDS · HARVARD MEDICAL SCHOOL · PI ARTAVANIS-TSAKONAS, SPYRIDON · 2010 to 2014
$6.7MSingle-Cell Approaches to Reveal How Jumping Genes Individualize Neural CircuitsR01MH095741 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI GAGE, FRED H · 2011 to 2015
$6.5MAn iPSC based platform for functionally assessing genetic and environmental riskR01NS088538 · NINDS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI JAENISCH, RUDOLF, MYERS, RICHARD H · 2014 to 2018
$5.0MDevelopment of new neurons in the adult brainR01NS047344 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SONG, HONGJUN · 2003 to 2011
$3.4MDISC1-dependent defects in neural fate, corticogenesis and cognition in psychosisR01MH105660 · NIMH · JOHNS HOPKINS UNIVERSITY · PI ISHIZUKA, KOKO, SAWA, AKIRA · 2014 to 2018
$2.8MMechanisms of circuit failure and treatments in patient-derived neurons in autismR01MH105442 · NIMH · BROWN UNIVERSITY · PI MORROW, ERIC M · 2014 to 2019
$2.8MContrasting causal microRNAs in forebrain and midbrain COS hiPSC neural cellsR01MH101454 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BRENNAND, KRISTEN JENNIFER · 2013 to 2017
$2.8MGene regulatory elements and transcriptome in iPSCs and embryonic human cortexU01MH103365 · NIMH · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, VACCARINO, FLORA M · 2014 to 2017
$2.4MMedical Research Council MC_UP_1201/9Medical Research Council MR/L023784/1Medical Research Council MR/L023784/2NCI NIH HHS P30 CA014195NIA NIH HHS RF1 AG042932NIA NIH HHS RF1AG042932NIMH NIH HHS 2R01MH104610NIMH NIH HHS P50 MH094268NIMH NIH HHS P50MH094268NIMH NIH HHS R01 MH089176NIMH NIH HHS R01MH089176NIMH NIH HHS R01 MH092443NIMH NIH HHS R01MH092443NIMH NIH HHS R01 MH094753NIMH NIH HHS R01MH094753NIMH NIH HHS R01 MH095741NIMH NIH HHS R01MH095741NIMH NIH HHS R01 MH101454NIMH NIH HHS R01MH101454NIMH NIH HHS R01 MH102418NIMH NIH HHS R01MH102418NIMH NIH HHS R01 MH103134NIMH NIH HHS R01MH103134NIMH NIH HHS R01 MH104610NIMH NIH HHS R01 MH105442NIMH NIH HHS R01MH105442NIMH NIH HHS R01 MH105660NIMH NIH HHS R01MH105660NIMH NIH HHS R21 MH087879NIMH NIH HHS R21MH087879NIMH NIH HHS R33 MH087874NIMH NIH HHS R33MH087874NIMH NIH HHS U01 MH103365NIMH NIH HHS U01MH1068821NIMH NIH HHS U19 MH107367NIMH NIH HHS U19MH107367NINDS NIH HHS P01 NS066888NINDS NIH HHS P01NS066888NINDS NIH HHS R01 NS047344NINDS NIH HHS R01NS047344NINDS NIH HHS R01 NS088538NINDS NIH HHS R01NS088538Wellcome Trust 101052
Abstract
As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.
Indexed as
NeurogenesisBrainBrain DiseasesDrug DiscoveryHumansInduced Pluripotent Stem CellsMosaicismPrecision Medicine
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