Evidence map›Paper›PMID 26610593›Full record

ArticleJournal of extracellular vesicles2015

Ginger-derived nanoparticles protect against alcohol-induced liver damage.

Xiaoying Zhuang, Zhong-Bin Deng, Jingyao Mu, Lifeng Zhang, Jun Yan, Donald Miller, Wenke Feng, Craig J McClain, Huang-Ge Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of extracellular vesicles, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 330 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
330citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

330 citing papers in PubMed, 2 syntheses or guidelines pooled it, 543 citations in OpenAlex.

  1. Pooled it
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  9. Natural Product-Derived Vesicles in Nanotherapeutics.Journal of extracellular vesicles · 2026
    Review
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270 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Xiaoying ZhuangJames Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, Louisville, KY, USA.
Zhong-Bin DengJames Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, Louisville, KY, USA.
Jingyao MuJames Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, Louisville, KY, USA.
Lifeng ZhangJames Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, Louisville, KY, USA.
Jun YanJames Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, Louisville, KY, USA.
Donald MillerJames Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, Louisville, KY, USA.
Wenke FengDivision of Gastroenterology, Department of Medicine, University of Louisville, Louisville, KY, USA.
Craig J McClainDivision of Gastroenterology, Department of Medicine, University of Louisville, Louisville, KY, USA.
Huang-Ge ZhangJames Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, Louisville, KY, USA.
University of Louisville · USJames Graham Brown Foundation · USLouisville VA Medical Center · US

Funding

Plant exosomes non-coding RNA-mediated anti-inflammatory mechanismsR01AT008617 · NCCIH · UNIVERSITY OF LOUISVILLE · PI HUANG-GE ZHANG · 2016 to 2026
$5.7M
Mechanisms of Probiotics in Alcoholic Liver DiseaseR01AA023190 · NIAAA · UNIVERSITY OF LOUISVILLE · PI FENG, WENKE · 2015 to 2024
$3.5M
Fruit exosome-like particles for therapeutic delivery of extracellular miRNAsUH3TR000875 · NCATS · UNIVERSITY OF LOUISVILLE · PI ZHANG, HUANG-GE · 2015 to 2017
$2.7M
Mechanisms for alcohol induced gut barrier dysfunction in ALDR01AA023681 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2014 to 2018
$1.6M
Curcumin reverses tumor exosomes-mediated inhibition of myeloid differentiationR01AT004294 · NCCIH · UNIVERSITY OF LOUISVILLE · PI ZHANG, HUANG-GE · 2007 to 2010
$1.4M
Fruit exosome-like particles for therapeutic delivery of extracellular miRNAsUH2TR000875 · NCATS · UNIVERSITY OF LOUISVILLE · PI GUO, PEIXUAN, ZHANG, HUANG-GE · 2013 to 2014
$867k
FGF21 and adipose lipolysis in alcoholic fatty liverR21AA022416 · NIAAA · UNIVERSITY OF LOUISVILLE · PI FENG, WENKE · 2014 to 2015
$388k
NCATS NIH HHS UH2 TR000875NCATS NIH HHS UH3 TR000875NCCIH NIH HHS R01 AT004294NCCIH NIH HHS R01 AT008617NIAAA NIH HHS R01 AA023190NIAAA NIH HHS R01 AA023681NIAAA NIH HHS R21 AA022416
6 · The paper itself

Abstract

Daily exposure of humans to nanoparticles from edible plants is inevitable, but significant advances are required to determine whether edible plant nanoparticles are beneficial to our health. Additionally, strategies are needed to elucidate the molecular mechanisms underlying any beneficial effects. Here, as a proof of concept, we used a mouse model to show that orally given nanoparticles isolated from ginger extracts using a sucrose gradient centrifugation procedure resulted in protecting mice against alcohol-induced liver damage. The ginger-derived nanoparticle (GDN)-mediated activation of nuclear factor erythroid 2-related factor 2 (Nrf2) led to the expression of a group of liver detoxifying/antioxidant genes and inhibited the production of reactive oxygen species, which partially contributes to the liver protection. Using lipid knock-out and knock-in strategies, we further identified that shogaol in the GDN plays a role in the induction of Nrf2 in a TLR4/TRIF-dependent manner. Given the critical role of Nrf2 in modulating numerous cellular processes, including hepatocyte homeostasis, drug metabolism, antioxidant defenses, and cell-cycle progression of liver, this finding not only opens up a new avenue for investigating GDN as a means to protect against the development of liver-related diseases such as alcohol-induced liver damage but sheds light on studying the cellular and molecular mechanisms underlying interspecies communication in the liver via edible plant-derived nanoparticles.

Indexed as

alcoholic liver injuryginger nanoparticlesNrf2 detoxic effectshogaolTLR4/TRIF pathway

Identifiers

PMID26610593
PMCPMC4662062
OpenAlexW2175705385

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.