ArticleInternational journal of molecular sciences2015
Metabolite Profile of Cervicovaginal Fluids from Early Pregnancy Is Not Predictive of Spontaneous Preterm Birth.
Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Vulvovaginal yeast infections during pregnancy and perinatal outcomes: systematic review and meta-analysis.BMC women's health · 2023Pooled it
- Metabolomics to reveal biomarkers and pathways of preterm birth: a systematic review and epidemiologic perspective.Metabolomics : Official journal of the Metabolomic Society · 2019Pooled it
- The plasma metabolome of women in early pregnancy differs from that of non-pregnant women.PloS one · 2019Trial
- Systematic review of preterm birth multi-omic biomarker studies.Expert reviews in molecular medicine · 2022Review
- Metabolites from midtrimester plasma of pregnant patients at high risk for preterm birth.American journal of obstetrics & gynecology MFM · 2021Article
- Maternal plasma metabolic markers of neonatal adiposity and associated maternal characteristics: The GUSTO study.Scientific reports · 2020Article
- Metabolomics applied to maternal and perinatal health: a review of new frontiers with a translation potential.Clinics (Sao Paulo, Brazil) · 2019Review
- Postnatal Subacute Benzo(a)Pyrene Exposure Caused Neurobehavioral Impairment and Metabolomic Changes of Cerebellum in the Early Adulthood Period of Sprague-Dawley Rats.Neurotoxicity research · 2018Article
- Translational Systems Pharmacology Studies in Pregnant Women.CPT: pharmacometrics & systems pharmacology · 2018Review
- Maternal Plasma Metabolomic Profiles in Spontaneous Preterm Birth: Preliminary Results.Mediators of inflammation · 2018Article
- Metabolites and metabolic pathways associated with glucocorticoid resistance in pregnant African-American women.Comprehensive psychoneuroendocrinologyArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In our study, we used a mass spectrometry-based metabolomic approach to search for biomarkers that may act as early indicators of spontaneous preterm birth (sPTB). Samples were selected as a nested case-control study from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Cervicovaginal swabs were collected at 20 weeks from women who were originally assessed as being at low risk of sPTB. Samples were analysed using gas chromatography-mass spectrometry (GC-MS). Despite the low amount of biomass (16-23 mg), 112 compounds were detected. Statistical analysis showed no significant correlations with sPTB. Comparison of reported infection and plasma inflammatory markers from early pregnancy showed two inflammatory markers were correlated with reported infection, but no correlation with any compounds in the metabolite profile was observed. We hypothesise that the lack of biomarkers of sPTB in the cervicovaginal fluid metabolome is simply because it lacks such markers in early pregnancy. We propose alternative biofluids be investigated for markers of sPTB. Our results lead us to call for greater scrutiny of previously published metabolomic data relating to biomarkers of sPTB in cervicovaginal fluids, as the use of small, high risk, or late pregnancy cohorts may identify metabolite biomarkers that are irrelevant for predicting risk in normal populations.
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Registered trials
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