ArticleMolecules (Basel, Switzerland)2015
Pyranocoumarins from Root Extracts of Peucedanum praeruptorum Dunn with Multidrug Resistance Reversal and Anti-Inflammatory Activities.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 51 citations in OpenAlex.
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- Protective effect ofExperimental and therapeutic medicine · 2023Article
- Identification of Anti-Inflammatory Compounds fromMolecules (Basel, Switzerland) · 2023Article
- Integrative analysis of chloroplast genome, chemicals, and illustrations in Bencao literature provides insights into the medicinal value ofFrontiers in plant science · 2023Article
- Plant Pyranocoumarins: Description, Biosynthesis, Application.Plants (Basel, Switzerland) · 2022Review
- Comparative Analysis of Coumarin Profiles in Different Parts ofMolecules (Basel, Switzerland) · 2022Article
- The Root Extract ofMolecules (Basel, Switzerland) · 2022Article
- Two new endemic species,PhytoKeys · 2022Article
- Comparative Transcriptomics Unveil the Crucial Genes Involved in Coumarin Biosynthesis inFrontiers in plant science · 2022Article
- Article
- Praeruptorin B Mitigates the Metastatic Ability of Human Renal Carcinoma Cells through Targeting CTSC and CTSV Expression.International journal of molecular sciences · 2020Article
- Tissue-Specific Metabolite Profiling on the Different Parts of Bolting and UnboltingMolecules (Basel, Switzerland) · 2019Article
- Praeruptorin A Inhibits Human Cervical Cancer Cell Growth and Invasion by Suppressing MMP-2 Expression and ERK1/2 Signaling.International journal of molecular sciences · 2017Article
- Evaluation of anti-tumorigenic activity of BP3B against colon cancer with patient-derived tumor xenograft model.BMC complementary and alternative medicine · 2016Article
- Natural and Synthetic Coumarins with Effects on Inflammation.Molecules (Basel, Switzerland) · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the search for novel herbal-based anticancer agents, we isolated a new angular-type pyranocoumarin, (+)-cis-(3'S,4'S)-3'-angeloyl-4'-tigloylkhellactone (1) along with 12 pyranocoumarins (2-13), two furanocoumarins (14, 15), and a polyacetylene (16) were isolated from the roots of Peucedanum praeruptorum using chromatographic separation methods. The structures of the compounds were determined using spectroscopic analysis with nuclear magnetic resonance (NMR) and high-resolution-electrospray ionization-mass spectrometry (HR-ESI-MS). The multidrug-resistance (MDR) reversal and anti-inflammatory effects of all the isolated compounds were evaluated in human sarcoma MES-SA/Dx5 and lipopolysaccharide (LPS)-induced RAW 264.7 cells. Among the 16 tested compounds, two (2 and 16) downregulated nitric oxide (NO) production and five (1, 7, 8, 11, and 13) inhibited the efflux of drugs by MDR protein, indicating the reversal of MDR. Therefore, these compounds may be potential candidates for the development of effective agents against MDR forms of cancer.
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