ReviewNeurochemical research2015
In Vivo NMR Studies of the Brain with Hereditary or Acquired Metabolic Disorders.
Review in Neurochemical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Establishment and Optimization of a Human Flow-Based Hollow FiberPharmaceutics · 2026Article
- Protective Effects ofLife (Basel, Switzerland) · 2025Article
- Urine amino acid and gamma aminobutyric acid level in COVID 19 patients.Iranian journal of microbiology · 2025Article
- Article
- Non-invasive in vivo measurements of metabolic alterations in the type 2 diabetic brain byJournal of neurochemistry · 2024Article
- NMR Spectroscopy in Diagnosis and Monitoring of Methylmalonic and Propionic Acidemias.Biomolecules · 2024Review
- Dietary intakes of methionine, threonine, lysine, arginine and histidine increased risk of type 2 diabetes in Chinese population: does the mediation effect of obesity exist?BMC public health · 2023Article
- Comparison of the gut microbiota and untargeted gut tissue metabolome of Chinese mitten crabs (Frontiers in microbiology · 2023Article
- A Prospective Study: Highlights of Hippocampal Spectroscopy in Cognitive Impairment in Patients with Type 1 and Type 2 Diabetes.Journal of personalized medicine · 2021Article
- Monitoring Methylmalonic Aciduria by NMR Urinomics.Molecules (Basel, Switzerland) · 2020Article
- Altered brain metabolites in patients with diabetes mellitus and related complications - evidence fromBioscience reports · 2018Review
- Imaging based magnetic resonance spectroscopy (MRS) localization for quantitative neurochemical analysis and cerebral metabolism studies.Analytical biochemistry · 2017Review
- Oligodendrocytes Do Not Export NAA-Derived Aspartate In Vitro.Neurochemical research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic disorders, whether hereditary or acquired, affect the brain, and abnormalities of the brain are related to cellular integrity; particularly in regard to neurons and astrocytes as well as interactions between them. Metabolic disturbances lead to alterations in cellular function as well as microscopic and macroscopic structural changes in the brain with diabetes, the most typical example of metabolic disorders, and a number of hereditary metabolic disorders. Alternatively, cellular dysfunction and degeneration of the brain lead to metabolic disturbances in hereditary neurological disorders with neurodegeneration. Nuclear magnetic resonance (NMR) techniques allow us to assess a range of pathophysiological changes of the brain in vivo. For example, magnetic resonance spectroscopy detects alterations in brain metabolism and energetics. Physiological magnetic resonance imaging (MRI) detects accompanying changes in cerebral blood flow related to neurovascular coupling. Diffusion and T1/T2-weighted MRI detect microscopic and macroscopic changes of the brain structure. This review summarizes current NMR findings of functional, physiological and biochemical alterations within a number of hereditary and acquired metabolic disorders in both animal models and humans. The global view of the impact of these metabolic disorders on the brain may be useful in identifying the unique and/or general patterns of abnormalities in the living brain related to the pathophysiology of the diseases, and identifying future fields of inquiry.
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