ArticleEnvironmental research2016
Presence of an epigenetic signature of prenatal cigarette smoke exposure in childhood.
Article in Environmental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Polymethylation scores for prenatal maternal smoke exposure persist until age 15 and are detected in saliva in the Fragile Families and Child Wellbeing cohort.Epigenetics · 2022Pooled it
- Development and Validation of a Novel Placental DNA Methylation Biomarker of Maternal Smoking during Pregnancy in the ECHO Program.Environmental health perspectives · 2024Trial
- Differential methylation at novel putative imprinting control regions on chromosome 20 associated with childhood obesity.Epigenetics · 2026Article
- Maternal exposure to fine particulate matter and autism spectrum disorder in children: population based case-control study.Frontiers in public health · 2026Article
- Environmental exposures and epigenetic alterations in common chronic diseases: insights and challenges.Environmental epigenetics · 2026Review
- The social context of educational effort - implications for psychological and physiological health in adolescence.Psychoneuroendocrinology · 2025Article
- Prenatal Tobacco and Alcohol Exposure and Cortical Change Among Youths.JAMA network open · 2025Article
- Progress in understanding Legg-Calvé-Perthes disease etiology from a molecular and cellular biology perspective.Frontiers in physiology · 2025Review
- Maternal smoking during pregnancy is associated with DNA methylation in early adolescence: A sibling comparison design.Developmental psychology · 2024Article
- Former smoking associated with epigenetic modifications in human granulosa cells among women undergoing assisted reproduction.Scientific reports · 2024Article
- Prenatal exposure to maternal smoking and adult lung cancer risk: a nested case-control study using peripheral blood leukocyte DNA methylation prediction of exposure.Environmental epigenetics · 2024Article
- Predicting Fetal Alcohol Spectrum Disorders Using Machine Learning Techniques: Multisite Retrospective Cohort Study.Journal of medical Internet research · 2023Article
- Towards AI-driven longevity research: An overview.Frontiers in aging · 2023Review
- Evaluation of nanopore sequencing for epigenetic epidemiology: a comparison with DNA methylation microarrays.Human molecular genetics · 2022Article
- Epigenome-wide association analyses of active injection drug use.Drug and alcohol dependence · 2022Article
- In utero exposure to electronic-cigarette aerosols decreases lung fibrillar collagen content, increases Newtonian resistance and induces sex-specific molecular signatures in neonatal mice.Toxicological research · 2022Article
- Epigenetic regulation of pediatric and neonatal immune responses.Pediatric research · 2022Review
- Article
- The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2021Article
- Epigenetic Alterations of Maternal Tobacco Smoking during Pregnancy: A Narrative Review.International journal of environmental research and public health · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 8 institutions in 2 countries.
Funding
Abstract
Prenatal exposure to tobacco smoke has lifelong health consequences. Epigenetic signatures such as differences in DNA methylation (DNAm) may be a biomarker of exposure and, further, might have functional significance for how in utero tobacco exposure may influence disease risk. Differences in infant DNAm associated with maternal smoking during pregnancy have been identified. Here we assessed whether these infant DNAm patterns are detectible in early childhood, whether they are specific to smoking, and whether childhood DNAm can classify prenatal smoke exposure status. Using the Infinium 450K array, we measured methylation at 26 CpG loci that were previously associated with prenatal smoking in infant cord blood from 572 children, aged 3-5, with differing prenatal exposure to cigarette smoke in the Study to Explore Early Development (SEED). Striking concordance was found between the pattern of prenatal smoking associated DNAm among preschool aged children in SEED and those observed at birth in other studies. These DNAm changes appear to be tobacco-specific. Support vector machine classification models and 10-fold cross-validation were applied to show classification accuracy for childhood DNAm at these 26 sites as a biomarker of prenatal smoking exposure. Classification models showed prenatal exposure to smoking can be assigned with 81% accuracy using childhood DNAm patterns at these 26 loci. These findings support the potential for blood-derived DNAm measurements to serve as biomarkers for prenatal exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.