ArticleNature2015
Complete nitrification by Nitrospira bacteria.
Article in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 659 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
659 citing papers in PubMed, 2,602 citations in OpenAlex.
- Active layer microbial inocula restore missing functions across thawed permafrost soils.Nature communications · 2026Article
- Niche specialization and prevalence of comammox Nitrospira in the alkaline sediments of thermokarst lakes on the Tibetan Plateau.Nature communications · 2026Article
- Asynchronous recovery of canonical ammonia oxidizers and comammox drives post-drought NWorld journal of microbiology & biotechnology · 2026Article
- Ecological significance of dark carbon fixation driven by ammonia oxidation in estuarine waters.Eco-Environment & Health · 2026Article
- Comparative phylogenomics of bacterial urease systems reveals architectural conservation, lineage-specific specialization, and candidate horizontal transfer.Molecular genetics and genomics : MGG · 2026Article
- Wastewater-Derived Comammox Nitrospira for Next-Generation Wastewater Management.Environmental science & technology · 2026Review
- Three Decades of Soil NGlobal change biology · 2026Review
- Bacterial community succession and functional gene dynamics of nitrogen and phosphorus cycling in recirculating aquaculture systems of shrimp.FEMS microbiology ecology · 2026Article
- A nitrification bioreactor applied solely with ammonium and inorganic C maintains a highly diverse bacterial and archaeal community even after nine years.Biodegradation · 2026Article
- Prolonged Stagnation Reduces Treated Wastewater Biostability by Altering Microbial Community: Insights From Metaproteomics.Environmental microbiology · 2026Article
- Different Ferromanganese Concretion Morphologies Host Distinct Microbial Communities and Metal Accumulation Patterns in the Baltic Sea.Environmental microbiology · 2026Article
- Elucidating the Role of Bacterial and Arbuscular Mycorrhizal Fungi Inoculants in Mitigating Nitrous Oxide (NMicroorganisms · 2026Review
- Transcriptionally active ammonia-oxidizing nitrifiers in a surface flow constructed wetland.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Effects of pristine and citrate-coated zinc oxide nanoparticles on soil nitrogen cycling determined using multi-level assessment of enzyme activity, functional gene abundance and microbial community composition.Environmental science and pollution research international · 2026Article
- The Elbe Estuary Microbiome Shifts With Salinity and Discharge and Depends on Fresh Organic Matter and Nutrient Availability.Environmental microbiology reports · 2026Article
- Shifts in soil microbiome surrounding a thermal treatment facility for hazardous waste: the hidden impact of environmentally persistent free radicals.Environmental science. Processes & impacts · 2026Article
- Metagenomic Insights into Regional Differences in the Rhizosphere Microbial Communities ofMicroorganisms · 2026Article
- Gradient Potassium Application Differentially Regulates Rhizosphere Bacterial and Fungal Communities in Cherry Tomato (Plants (Basel, Switzerland) · 2026Article
- Ammonia monooxygenase: a work in progress.Chemical science · 2026Review
- Harnessing the Infectivity and Stability of Bacteriophage ΦNF-1 in a Phage-Based Product for Sustainable Nitrification Control.Environmental science & technology · 2026Article
599 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors at 5 institutions in 4 countries.
Funding
Abstract
Nitrification, the oxidation of ammonia via nitrite to nitrate, has always been considered to be a two-step process catalysed by chemolithoautotrophic microorganisms oxidizing either ammonia or nitrite. No known nitrifier carries out both steps, although complete nitrification should be energetically advantageous. This functional separation has puzzled microbiologists for a century. Here we report on the discovery and cultivation of a completely nitrifying bacterium from the genus Nitrospira, a globally distributed group of nitrite oxidizers. The genome of this chemolithoautotrophic organism encodes the pathways both for ammonia and nitrite oxidation, which are concomitantly activated during growth by ammonia oxidation to nitrate. Genes affiliated with the phylogenetically distinct ammonia monooxygenase and hydroxylamine dehydrogenase genes of Nitrospira are present in many environments and were retrieved on Nitrospira-contigs in new metagenomes from engineered systems. These findings fundamentally change our picture of nitrification and point to completely nitrifying Nitrospira as key components of nitrogen-cycling microbial communities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.