Evidence map›Paper›PMID 26609956›Full record

ArticleDevelopmental cell2015

Semi-permeable Diffusion Barriers Enhance Patterning Robustness in the C. elegans Germline.

Amanda Cinquin, Likun Zheng, Pete H Taylor, Adrian Paz, Lei Zhang, Michael Chiang, Joshua J Snow, Qing Nie, Olivier Cinquin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. A toolkit of taggedmicroPublication biology · 2020
    Article
  7. Biology of theGenetics · 2019
    Review
  8. Article
  9. Article
  10. Article
  11. eLife · 2016
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Amanda CinquinDepartment of Developmental and Cell Biology, University of California at Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California at Irvine, Irvine, CA 92697, USA.
Likun ZhengDepartment of Mathematics, University of California at Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California at Irvine, Irvine, CA 92697, USA.
Pete H TaylorDepartment of Developmental and Cell Biology, University of California at Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California at Irvine, Irvine, CA 92697, USA.
Adrian PazDepartment of Developmental and Cell Biology, University of California at Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California at Irvine, Irvine, CA 92697, USA.
Lei ZhangDepartment of Mathematics, University of California at Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California at Irvine, Irvine, CA 92697, USA.
Michael ChiangDepartment of Developmental and Cell Biology, University of California at Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California at Irvine, Irvine, CA 92697, USA.
Joshua J SnowDepartment of Biochemistry, University of Wisconsin at Madison, Madison, WI 53706, USA.
Qing NieDepartment of Mathematics, University of California at Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California at Irvine, Irvine, CA 92697, USA.
Olivier CinquinDepartment of Developmental and Cell Biology, University of California at Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California at Irvine, Irvine, CA 92697, USA. Electronic address: olivier.cinquin@uci.edu.
University of California, Irvine · USUniversity of Wisconsin–Madison · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Uncover Strategies Used By Biological SystemsP50GM076516 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GRATTON, ENRICO · 2007 to 2016
$25.1M
Biomedical Informatics Training ProgramT15LM007443 · NLM · UNIVERSITY OF CALIFORNIA-IRVINE · PI BALDI, PIERRE · 2002 to 2012
$9.3M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Principles of Robust Developmental PatterningR01GM067247 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LANDER, ARTHUR D, NIE, QING · 2002 to 2014
$4.7M
Mathematical, Computational and Systems BiologyT32EB009418 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI LANDER, ARTHUR D, NIE, QING · 2009 to 2019
$2.4M
Control of cell cycling speed to delay the onset of senescenceR01GM102635 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CINQUIN, OLIVIER · 2012 to 2016
$1.4M
Stochastic Dynamics and Noise Control in Patterning SystemsR01GM107264 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI NIE, QING, SCHILLING, THOMAS F · 2014 to 2017
$1.3M
Training Program in Systems Biology of DevelopmentT32HD060555 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI LANDER, ARTHUR D · 2009 to 2013
$1.3M
Direct tests of the role of stem cells in minimizing mutation accumulationR21AG042125 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CINQUIN, OLIVIER · 2012 to 2013
$396k
NCI NIH HHS CA-62203NCI NIH HHS P30 CA062203NIA NIH HHS R21 AG042125NIA NIH HHS R21-AG042125NIBIB NIH HHS T32 EB009418NIBIB NIH HHS T32-EB009418NICHD NIH HHS T32 HD060555NICHD NIH HHS T32-HD060555NIGMS NIH HHS P50 GM076516NIGMS NIH HHS P50-GM076516NIGMS NIH HHS R01 GM067247NIGMS NIH HHS R01 GM102635NIGMS NIH HHS R01-GM102635NIGMS NIH HHS R01 GM107264NIGMS NIH HHS R01-GM107264NIGMS NIH HHS R01-GM67247NIH HHS P40 OD010440NIH HHS P40-OD010440NLM NIH HHS T15 LM007443NLM NIH HHS T15-LM007443
6 · The paper itself

Abstract

Positional information derived from local morphogen concentration plays an important role in patterning. A key question is how morphogen diffusion and gene expression regulation shape positional information into an appropriate profile with suitably low noise. We address this question using a model system--the C. elegans germline--whose regulatory network has been well characterized genetically but whose spatiotemporal dynamics are poorly understood. We show that diffusion within the germline syncytium is a critical control of stem cell differentiation and that semi-permeable diffusion barriers present at key locations make it possible--in combination with a feedback loop in the germline regulatory network--for mitotic zone size to be robust against spatial noise in Notch signaling. Spatial averaging within compartments defined by diffusion barriers is an advantageous patterning strategy, which attenuates noise while still allowing for sharp transitions between compartments. This strategy could apply to other organs.

Indexed as

Cell DifferentiationGene Expression Regulation, DevelopmentalAnimalsBody PatterningCaenorhabditis elegansFeedback, PhysiologicalGerm CellsModels, BiologicalReceptors, NotchSignal TransductionStem CellsReceptors, Notch

Identifiers

PMID26609956
PMCPMC4694723
OpenAlexW2177644504

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.