ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2015
Molecular, serological and in vitro culture-based characterization of Bourbon virus, a newly described human pathogen of the genus Thogotovirus.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Functional divergence of the Bhanja virus NSs protein modulates interferon antagonism and viral fitness across divergent lineages.PLoS pathogens · 2026Article
- Molecular Surveillance Reveals Diverse Tick-Borne Pathogens in Northern California.Pathogens (Basel, Switzerland) · 2026Article
- Park Size and Trail Environment Influence the Seasonal Transmission Risk of Tick-Borne Pathogens in Nashville Metropolitan Area Parks, Tennessee.The American journal of tropical medicine and hygiene · 2025Article
- ANP32 proteins from ticks and vertebrates are key host factors for replication of Bourbon virus across species.Journal of virology · 2025Article
- Surveillance for Serological Evidence of Bourbon and Heartland Virus Infection in White-Tailed Deer and Feral Swine in Texas.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2025Article
- Serosurveillance Identifies Bourbon Virus-Neutralizing Antibodies in Bobcats, Coyotes, and Red Foxes in Missouri.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2025Article
- Structure-guided drug repurposing and dynamics simulation reveal anti-viral candidates for Bourbon virus.In silico pharmacology · 2025Article
- Ticks and tick-borne diseases in the northern hemisphere affecting humans.Frontiers in microbiology · 2025Review
- Heartland Virus Infection in Elderly Patient Initially Suspected of Having Ehrlichiosis, North Carolina, USA.Emerging infectious diseases · 2024Article
- Tick-borne viruses: Epidemiology, pathogenesis, and animal models.One health (Amsterdam, Netherlands) · 2024Review
- Evidence of Lineage 1 and 3 West Nile Virus in Person with Neuroinvasive Disease, Nebraska, USA, 2023.Emerging infectious diseases · 2024Article
- Serosurveillance and the first detection of Bourbon virus RNA in a wildlife host.bioRxiv : the preprint server for biology · 2024Article
- Widespread Circulation of Tick-Borne Viruses in Virginia-Evidence of Exposure to Heartland, Bourbon, and Powassan Viruses in Wildlife and Livestock.Microorganisms · 2024Article
- Diversification of Bourbon Virus in New York State.Microorganisms · 2023Article
- Prevalence of Bourbon and Heartland viruses in field collected ticks at an environmental field station in St. Louis County, Missouri, USA.Ticks and tick-borne diseases · 2023Article
- Bourbon Virus Transmission, New York, USA.Emerging infectious diseases · 2023Article
- Geographical distribution and pathogenesis of ticks and tick-borne viral diseases.Frontiers in microbiology · 2023Review
- Comprehensive Review of Emergence and Virology of Tickborne Bourbon Virus in the United States.Emerging infectious diseases · 2023Review
- Generation of Multiple Arbovirus-like Particles Using a Rapid Recombinant Vaccinia Virus Expression Platform.Pathogens (Basel, Switzerland) · 2022Article
- Dermatological manifestations of tick-borne viral infections found in the United States.Virology journal · 2022Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundIn June of 2014, a previously healthy man from Kansas with a recent history of tick exposure died from complications related to an illness marked by fever, thrombocytopenia and leukopenia. An isolate was derived from the blood of this patient during the course of diagnostic testing. This isolate was subsequently identified as a novel orthomyxovirus of the genus Thogotovirus by next generation sequencing and was named Bourbon virus after the patient's county of residence.
objectivesTo support research and diagnostic aims, we provide a basic description of Bourbon virus at both the molecular and serological levels. Furthermore, to preliminarily identify potential host and vector range associations we have characterized the growth kinetics of Bourbon virus in a variety of vertebrate and invertebrate cell lines. STUDY
designBourbon virus was subjected to next generation-high throughput sequencing, phylogenetic, and basic structural protein analyses as well as 2-way plaque reduction neutralization assays. Also, we inoculated a variety of cell types with Bourbon virus and evaluated the growth kinetics by determining viral titers in the supernatants taken from infected cells over time.
resultsBourbon virus possesses 24-82% identity at the amino acid sequence level and low serological cross-reactivity with other Thogotoviruses. In vitro growth kinetics reveal robust replication of Bourbon virus in mammalian and tick cells.
conclusionsMolecular and serological characterizations identify Bourbon virus as a novel member of the genus Thogotovirus. Results from cell culture analyses suggest an association between Bourbon virus and mammalian and tick hosts.
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