ArticleRedox biology2016
L-dehydroascorbic acid can substitute l-ascorbic acid as dietary vitamin C source in guinea pigs.
Article in Redox biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Comparative study of reproductive and preweaning performance in meat guinea pigs located in two housing systems.Tropical animal health and production · 2026Article
- Untargeted metabolomics as a tool to assess the impact of dietary approaches on pig gut health: a review.Journal of animal science and biotechnology · 2025Review
- Dehydroascorbic acid sensitizes cancer cells to system xCell death & disease · 2023Article
- Increasing vitamin C through agronomic biofortification of arugula microgreens.Scientific reports · 2022Article
- The relationship between nutrition and the immune system.Frontiers in nutrition · 2022Review
- Neonatal Vitamin C and Cysteine Deficiencies Program Adult Hepatic Glutathione and Specific Activities of Glucokinase, Phosphofructokinase, and Acetyl-CoA Carboxylase in Guinea Pigs' Livers.Antioxidants (Basel, Switzerland) · 2021Article
- Review
- Nutritional value of some raw materials for guinea pigs (Translational animal science · 2021Article
- On the effect of vitamin C intake on human health: How to (mis)interprete the clinical evidence.Redox biology · 2020Review
- Resveratrol potentiates intracellular ascorbic acid enrichment through dehydroascorbic acid transport and/or its intracellular reduction in HaCaT cells.Molecular and cellular biochemistry · 2020Article
- The Long History of Vitamin C: From Prevention of the Common Cold to Potential Aid in the Treatment of COVID-19.Frontiers in immunology · 2020Review
- Total Vitamin C, Ascorbic Acid, Dehydroascorbic Acid, Antioxidant Properties, and Iron Content of Underutilized and Commonly Consumed Fruits in Sri Lanka.International journal of food science · 2020Article
- The Pharmacokinetics of Vitamin C.Nutrients · 2019Review
- The influence of cellular senescence on intracellular vitamin C transport, accumulation, and function.Molecular and cellular biochemistry · 2018Article
- The rat closely mimics oxidative stress and inflammation in humans after exercise but not after exercise combined with vitamin C administration.European journal of applied physiology · 2016Article
- Comparative Physiological and Transcriptional Analyses of Two Contrasting Drought Tolerant Alfalfa Varieties.Frontiers in plant science · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin C deficiency globally affects several hundred million people and has been associated with increased morbidity and mortality in numerous studies. In this study, bioavailability of the oxidized form of vitamin C (l-dehydroascorbic acid or DHA)-commonly found in vitamin C containing food products prone to oxidation-was studied. Our aim was to compare tissue accumulation of vitamin C in guinea pigs receiving different oral doses of either ascorbate or DHA. In all tissues tested (plasma, liver, spleen, lung, adrenal glands, kidney, muscle, heart, and brain), only sporadic differences in vitamin C accumulation from ascorbate or DHA were observed except for the lowest dose of DHA (0.25mg/ml in the drinking water), where approximately half of the tissues had slightly yet significantly less vitamin C accumulation than from the ascorbate source. As these results contradicted data from rats, we continued to explore the ability to recycle DHA in blood, liver and intestine in guinea pigs, rats and mice. These investigations revealed that guinea pigs have similar recycling capacity in red blood cells as observed in humans, while rats and mice do not have near the same ability to reduce DHA in erythrocytes. In liver and intestinal homogenates, guinea pigs also showed a significantly higher ability to recycle DHA compared to rats and mice. These data demonstrate that DHA in guinea pigs-as in humans-is almost as effective as ascorbate as vitamin C source when it comes to taking up and storing vitamin C and further suggest that the guinea pig is superior to other rodents in modeling human vitamin C homeostasis.
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