Evidence map›Paper›PMID 26609504›Full record

ArticleSpringerPlus2015

Behavioral effects of mefloquine in tail suspension and light/dark tests.

John Michael Holden, Richard Slivicki, Rachel Dahl, Xia Dong, Matt Dwyer, Weston Holley, Crissa Knott

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in SpringerPlus, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

John Michael HoldenDepartment of Psychology, Winona State University, Phelps Hall 230-B, Winona, MN 55987 USA.
Richard SlivickiDepartment of Psychology, Winona State University, Phelps Hall 230-B, Winona, MN 55987 USA ; Indiana University, Bloomington, USA.
Rachel DahlDepartment of Psychology, Winona State University, Phelps Hall 230-B, Winona, MN 55987 USA.
Xia DongDepartment of Psychology, Winona State University, Phelps Hall 230-B, Winona, MN 55987 USA.
Matt DwyerDepartment of Psychology, Winona State University, Phelps Hall 230-B, Winona, MN 55987 USA.
Weston HolleyDepartment of Psychology, Winona State University, Phelps Hall 230-B, Winona, MN 55987 USA.
Crissa KnottDepartment of Psychology, Winona State University, Phelps Hall 230-B, Winona, MN 55987 USA.
Winona State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mefloquine hydrochloride has been used widely in the past few decades for malaria prophylaxis and treatment. However, in recent years, it has fallen out of favor due to reports of exposure being linked to numerous neuropsychiatric effects, including emotional disturbances. In this study we examined the effects of different doses (5, 25, or 100 mg/kg) of mefloquine relative to vehicle on male C57BL/6 J mice in two tests of emotional behavior, the light-dark box and the tail suspension test. It was found that mefloquine exposure reduced anxiety-linked behaviors in the light-dark box and reduced total immobility times in the tail suspension test, especially at higher doses. Our results lend support to the notion that mefloquine exposure could induce emotional disinhibition.

Indexed as

EmotionLight–dark boxMalariaMefloquineMiceTail suspension

Identifiers

PMID26609504
PMCPMC4648841
OpenAlexW2179553996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.