Evidence map›Paper›PMID 26609232›Full record

ArticleInternational journal of nanomedicine2015

Engineering iodine-doped carbon dots as dual-modal probes for fluorescence and X-ray CT imaging.

Miaomiao Zhang, Huixiang Ju, Li Zhang, Mingzhong Sun, Zhongwei Zhou, Zhenyu Dai, Lirong Zhang, Aihua Gong, Chaoyao Wu, Fengyi Du

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Nanotheranostics · 2023
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Recent Advances in Functional Carbon Quantum Dots for Antitumour.International journal of nanomedicine · 2021
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Heavy carbon nanodots: a new phosphorescent carbon nanostructure.Physical chemistry chemical physics : PCCP · 2018
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Miaomiao ZhangSchool of Medicine, Jiangsu University, Zhenjiang, People's Republic of China.
Huixiang JuDepartment of Clinical Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu, People's Republic of China.
Li ZhangSchool of Medicine, Jiangsu University, Zhenjiang, People's Republic of China.
Mingzhong SunDepartment of Clinical Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu, People's Republic of China.
Zhongwei ZhouDepartment of Clinical Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu, People's Republic of China.
Zhenyu DaiRadiology Department, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu, People's Republic of China.
Lirong ZhangSchool of Medicine, Jiangsu University, Zhenjiang, People's Republic of China.
Aihua GongSchool of Medicine, Jiangsu University, Zhenjiang, People's Republic of China.
Chaoyao WuSchool of Medicine, Jiangsu University, Zhenjiang, People's Republic of China.
Fengyi DuSchool of Medicine, Jiangsu University, Zhenjiang, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

X-ray computed tomography (CT) is the most commonly used imaging technique for noninvasive diagnosis of disease. In order to improve tissue specificity and prevent adverse effects, we report the design and synthesis of iodine-doped carbon dots (I-doped CDs) as efficient CT contrast agents and fluorescence probe by a facile bottom-up hydrothermal carbonization process. The as-prepared I-doped CDs are monodispersed spherical nanoparticles (a diameter of ~2.7 nm) with favorable dispersibility and colloidal stability in water. The aqueous solution of I-doped CDs showed wavelength-dependent excitation and stable photoluminescence similar to traditional carbon quantum dots. Importantly, I-doped CDs displayed superior X-ray attenuation properties in vitro and excellent biocompatibility. After intravenous injection, I-doped CDs were distributed throughout the body and excreted by renal clearance. These findings validated that I-doped CDs with high X-ray attenuation potency and favorable photoluminescence show great promise for biomedical research and disease diagnosis.

Indexed as

Tomography, X-Ray ComputedAnimalsCarbonCell DeathCell Line, TumorFluorescenceHumansIodineMiceMolecular ProbesNanotechnologyOptical ImagingQuantum DotsTissue DistributionX-Ray DiffractionCarbonIodineMolecular Probescarbon dotscontrast agentsCT imagingiodine-doped

Identifiers

PMID26609232
PMCPMC4644166

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.