Evidence map›Paper›PMID 26609122›Full record

Trial reportSchizophrenia bulletin2016

Trauma-Focused Treatment in PTSD Patients With Psychosis: Symptom Exacerbation, Adverse Events, and Revictimization.

David P G van den Berg, Paul A J M de Bont, Berber M van der Vleugel, Carlijn de Roos, Ad de Jongh, Agnes van Minnen, Mark van der Gaag

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03991377 (A Multicenter Phase II Rater-blinded Randomized Controlled Trial), which is not on this map. Cited by 48 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 5 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03991377 naunknown statusnot on this mapstarted 2019, after this paper: background citation

A Multicenter Phase II Rater-blinded Randomized Controlled Trial (RCT) to Compare Effectiveness of Eye Movement Desensitization Reprocessing Therapy (EMDR) vs Treatment as Usual (TAU) in First Episode Psychosis and History of Trauma.

TypeinterventionalSponsorParc de Salut MarRan2019 to 2024Enrolled71ConditionsPsychotic Episode, Psychological TraumaArmsEye movement desensitization and reprocessing therapy, Treatment as usual
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 5 syntheses or guidelines pooled it, 146 citations in OpenAlex.

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  3. Revictimisation Across Types of Interpersonal Violence: A Meta-Regression Analysis of PTSD and Associated Factors.Stress and health : journal of the International Society for the Investigation of Stress · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 2 countries.

David P G van den BergParnassia Psychiatric Institute, Zoutkeetsingel 40, 2512 HN Den Haag, The Netherlands; d.vandenberg@parnassia.nl.
Paul A J M de BontMental Health Organization (MHO) GGZ Oost Brabant Land van Cuijk en Noord Limburg, Boxmeer, The Netherlands;
Berber M van der VleugelCommunity Mental Health Service GGZ Noord-Holland Noord, Alkmaar, The Netherlands;
Carlijn de RoosMHO Rivierduinen, Leiden, The Netherlands;
Ad de JonghDepartment of Behavioral Sciences, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands; School of Health Sciences, Salford University, Manchester, UK;
Agnes van MinnenBehavioural Science Institute, NijCare, Radboud University Nijmegen, Nijmegen, The Netherlands; MHO Pro Persona, Centre for Anxiety Disorders Overwaal, Nijmegen, The Netherlands;
Mark van der GaagParnassia Psychiatric Institute, Zoutkeetsingel 40, 2512 HN Den Haag, The Netherlands; Department of Clinical Psychology, VU University Amsterdam and EMGO Institute for Health and Care Research, Amsterdam, The Netherlands.
EMGO Institute for Health and Care Research · NLGGZ Noord-Holland-Noord · NLGGZ Oost Brabant · NLGGZ Rivierduinen · NLParnassia Groep · NLRadboud University Nijmegen · NLUniversity of Salford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesMost clinicians refrain from trauma treatment for patients with psychosis because they fear symptom exacerbation and relapse. This study examined the negative side effects of trauma-focused (TF) treatment in patients with psychosis and posttraumatic stress disorder (PTSD).

methodsAnalyses were conducted on data from a single-blind randomized controlled trial comparing TF treatment (N = 108; 8 sessions prolonged exposure or eye movement desensitization) and waiting list (WL; N = 47) among patients with a lifetime psychotic disorder and current chronic PTSD. Symptom exacerbation, adverse events, and revictimization were assessed posttreatment and at 6-month follow-up. Also investigated were symptom exacerbation after initiation of TF treatment and the relationship between symptom exacerbation and dropout.

resultsAny symptom exacerbation (PTSD, paranoia, or depression) tended to occur more frequently in the WL condition. After the first TF treatment session, PTSD symptom exacerbation was uncommon. There was no increase of hallucinations, dissociation, or suicidality during the first 2 sessions. Paranoia decreased significantly during this period. Dropout was not associated with symptom exacerbation. Compared with the WL condition, fewer persons in the TF treatment condition reported an adverse event (OR = 0.48, P = .032). Surprisingly, participants receiving TF treatment were significantly less likely to be revictimized (OR = 0.40, P = .035).

conclusionsIn these participants, TF treatment did not result in symptom exacerbation or adverse events. Moreover, TF treatment was associated with significantly less exacerbation, less adverse events, and reduced revictimization compared with the WL condition. This suggests that conventional TF treatment protocols can be safely used in patients with psychosis without negative side effects.

Indexed as

Outcome Assessment, Health CareAdultComorbidityEye Movement Desensitization ReprocessingFemaleFollow-Up StudiesHumansImplosive TherapyMaleMiddle AgedPsychotic DisordersSingle-Blind MethodStress Disorders, Post-Traumaticadversitiessafetyschizophreniatrauma

Identifiers

PMID26609122
PMCPMC4838096
OpenAlexW2179855908

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.