ArticleScientific reports2015
Resting-state cerebellar-cerebral networks are differently affected in first-episode, drug-naive schizophrenia patients and unaffected siblings.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Intermittent theta burst stimulation of cerebellar vermis enhances fronto-cerebellar resting state functional connectivity in schizophrenia with predominant negative symptoms: A randomized controlled trial.Schizophrenia research · 2021Trial
- Effectiveness of a Combined High-Definition tDCS-Primed Intermittent Theta Burst Stimulation Protocol Targeting the Cerebellar Vermis in Treatment-Resistant Schizophrenia: a Randomized Sham-Controlled Trial.Cerebellum (London, England) · 2026Article
- Filtering the noise: a cerebellar-centered framework for understanding and treating mental illness -a paradigm shift in psychiatry.Frontiers in psychiatry · 2026Article
- Cerebellar-Cortical Connectivity and Prediction of Antipsychotic Treatment Response in First-Episode Psychosis.Schizophrenia bulletin · 2025Article
- Imaging Biomarker Studies of Antipsychotic-Naïve First-Episode Schizophrenia in China: Progress and Future Directions.Schizophrenia bulletin · 2025Review
- Widespread Intra- and Inter-Network Dysconnectivity among Large-Scale Resting State Networks in Schizophrenia.Journal of clinical medicine · 2023Article
- Cerebellar transcranial magnetic stimulation in psychotic disorders: intermittent, continuous, and sham theta-burst stimulation on time perception and symptom severity.Frontiers in psychiatry · 2023Article
- Cerebellar Structure and Cognitive Ability in Psychosis.Biological psychiatry · 2022Article
- Triple Network Functional Connectivity During Acute Stress in Adolescents and the Influence of Polyvictimization.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Resting-state functional MRI language network connectivity differences in patients with brain tumors: exploration of the cerebellum and contralesional hemisphere.Brain imaging and behavior · 2022Article
- Big contributions of the little brain for precision psychiatry.Frontiers in psychiatry · 2022Article
- Dynamic Altered Amplitude of Low-Frequency Fluctuations in Patients With Major Depressive Disorder.Frontiers in psychiatry · 2021Article
- Comparative Study on the Functional Connectivity of Amygdala and Hippocampal Neural Circuits in Patients With First-Episode Schizophrenia and Other High-Risk Populations.Frontiers in psychiatry · 2021Article
- Auditory hallucinations across the psychosis spectrum: Evidence of dysconnectivity involving cerebellar and temporal lobe regions.NeuroImage. Clinical · 2021Article
- Cerebellar-cortical dysconnectivity in resting-state associated with sensorimotor tasks in schizophrenia.Human brain mapping · 2020Article
- Multivariate classification of schizophrenia and its familial risk based on load-dependent attentional control brain functional connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Functional Connectivity Evoked by Orofacial Tactile Perception of Velocity.Frontiers in neuroscience · 2020Article
- Cognitive Profiles and Functional Connectivity in First-Episode Schizophrenia Spectrum Disorders - Linking Behavioral and Neuronal Data.Frontiers in psychology · 2019Article
- Enhanced Global-Brain Functional Connectivity in the Left Superior Frontal Gyrus as a Possible Endophenotype for Schizophrenia.Frontiers in neuroscience · 2019Article
- Dynamic functional connectivity impairments in early schizophrenia and clinical high-risk for psychosis.NeuroImage · 2018Article
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8 authors.
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Abstract
Dysconnectivity hypothesis posits that schizophrenia is a disorder with dysconnectivity of the cortico-cerebellar-thalamic-cortical circuit (CCTCC). However, it remains unclear to the changes of the cerebral connectivity with the cerebellum in schizophrenia patients and unaffected siblings. Forty-nine patients with first-episode, drug-naive schizophrenia patients, 46 unaffected siblings of schizophrenia patients and 46 healthy controls participated in the study. Seed-based resting-state functional connectivity approach was employed to analyze the data. Compared with the controls, the patients and the siblings share increased default-mode network (DMN) seed - right Crus II connectivity. The patients have decreased right dorsal attention network (DAN) seed - bilateral cerebellum 4,5 connectivity relative to the controls. By contrast, the siblings exhibit increased FC between the right DAN seed and the right cerebellum 6 and right cerebellum 4,5 compared to the controls. No other abnormal connectivities (executive control network and salience network) are observed in the patients/siblings relative to the controls. There are no correlations between abnormal cerebellar-cerebral connectivities and clinical variables. Cerebellar-cerebral connectivity of brain networks within the cerebellum are differently affected in first-episode, drug-naive schizophrenia patients and unaffected siblings. Increased DMN connectivity with the cerebellum may serve as potential endophenotype for schizophrenia.
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