ArticleBiomedical engineering online2015
The role of the circle of Willis in internal carotid artery stenosis and anatomical variations: a computational study based on a patient-specific three-dimensional model.
Article in Biomedical engineering online, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Computational Fluid Dynamics Analysis of Cerebrovascular Hemodynamic Differences in Adults with Sickle Cell Disease: Comparing Stroke and Non-Stroke Cohorts.Annals of biomedical engineering · 2026Article
- Article
- Posterior communicating artery vasospasm impairs cerebral pulsatility in an experimental subarachnoid hemorrhage model.Frontiers in neurology · 2025Article
- Anatomical study of variations in the configurations of the circle of Willis in relation to age, sex, and diameters of the components.Anatomy & cell biology · 2024Article
- Multi-Dimensional Modeling of Cerebral Hemodynamics: A Systematic Review.Bioengineering (Basel, Switzerland) · 2024Review
- Numerical study on the cerebral blood flow regulation in the circle of Willis with the vascular absence and internal carotid artery stenosis.Frontiers in bioengineering and biotechnology · 2024Article
- High resolution simulation of basilar artery infarct and flow within the circle of Willis.Scientific reports · 2023Article
- Article
- Predicting brain temperature in humans using bioheat models: Progress and outlook.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Review
- Median nerve somatosensory evoked potential alarm related to head and neck positioning for carotid surgery.Journal of clinical monitoring and computing · 2023Article
- Quantification of the Tissue Oxygenation Delay Induced by Breath-Holding in Patients with Carotid Atherosclerosis.Metabolites · 2022Article
- Evaluation of Circle of Willis variants using magnetic resonance angiography.Scientific reports · 2022Article
- Investigation of Flow Changes in Intracranial Vascular Disease Models Constructed with MRA Images.Sensors (Basel, Switzerland) · 2022Article
- Haemodynamic Analysis of Branched Endografts for Complex Aortic Arch Repair.Bioengineering (Basel, Switzerland) · 2022Article
- Determination of the Unilaterally Damaged Region May Depend on the Asymmetry of Carotid Blood Flow Velocity in Hemiparkinsonian Monkey: A Pilot Study.Parkinson's disease · 2022Article
- Circle of Willis variants and their association with outcome in patients with middle cerebral artery-M1-occlusion stroke.European journal of neurology · 2021Article
- Morphologic variants of the Cerebral Arterial Circle on computed tomographic angiography (CTA): a large retrospective study.Surgical and radiologic anatomy : SRA · 2021Article
- PIV investigation of the flow fields in subject-specific vertebro-basilar (VA-BA) junction.Biomedical engineering online · 2019Article
- Mapping the collaterome for precision cerebrovascular health: Theranostics in the continuum of stroke and dementia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Review
- Investigation of circle of Willis variants and hemodynamic parameters in twins using transcranial color-coded Doppler sonography.The international journal of cardiovascular imaging · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study is to provide better insights into the cerebral perfusion patterns and collateral mechanism of the circle of Willis (CoW) under anatomical and pathological variations.
methodsIn the current study, a patient-specific three-dimensional computational model of the CoW was reconstructed based on the computed tomography (CT) images. The Carreau model was applied to simulate the non-Newtonian property of blood. Flow distributions in five common anatomical variations coexisting with different degrees of stenosis in the right internal carotid artery (RICA) were investigated to obtain detailed flow information.
resultsWith the development of stenosis in unilateral internal carotid artery (ICA), the cerebral blood supply decreased when the degree of stenosis increased. The blood supply of the ipsilateral middle cerebral artery (MCA) was most affected by the stenosis of ICA. The anterior communicating artery (ACoA) and ipsilateral posterior communicating artery (PCoA) functioned as the important collateral circulation channels when unilateral stenosis occurred. The blood flow of the anterior circulation and the total cerebral blood flow (CBF) reached to the minimum in the configuration of the contralateral proximal anterior cerebral artery (A1) absence coexisting with unilateral ICA stenosis.
conclusionsCommunicating arteries provided important collateral channels in the complete CoW when stenosis in unilateral ICA occurred. The cross-flow in the ACoA is a sensitive indicator of the morphological change of the ICA. The collateral function of the PCoA on the affected side will not be fully activated until a severe stenosis occurred in unilateral ICA. The absence of unilateral A1 coexisting with the stenosis in the contralateral ICA could be the most dangerous configuration in terms of the total cerebral blood supply. The findings of this study would enhance the understanding of the collateral mechanism of the CoW under different anatomical variations.
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