Evidence map›Paper›PMID 26608807›Full record

ReviewProgress in retinal and eye research2016

Molecular diagnosis: Implications for ophthalmology.

James T Rosenbaum, Cailin H Sibley, Dongseok Choi, Christina A Harrington, Stephen R Planck

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in retinal and eye research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. The Role of the Ubiquitin System in Eye Diseases.Life (Basel, Switzerland) · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Ocular sarcoidosis: new diagnostic modalities and treatment.Current opinion in pulmonary medicine · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James T RosenbaumDevers Eye Institute, Legacy Health Systems, 1040 NW 22nd Avenue, Portland, OR 97210, USA; Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239, USA; Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA. Electronic address: rosenbaj@ohsu.edu.
Cailin H SibleyDepartment of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA. Electronic address: sibleyc@ohsu.edu.
Dongseok ChoiDepartment of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239, USA; Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA; OHSU-PSU School of Public Health, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address: choid@ohsu.edu.
Christina A HarringtonIntegrated Genomics Laboratory, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA. Electronic address: harringc@ohsu.edu.
Stephen R PlanckDevers Eye Institute, Legacy Health Systems, 1040 NW 22nd Avenue, Portland, OR 97210, USA; Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239, USA; Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA. Electronic address: plancks@ohsu.edu.

Funding

Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI KIRSTEN Jeanne LAMPI · 1995 to 2026
$19.4M
Gene Expression in Nonspecific Orbital Inflammatory DiseaseR01EY020249 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ROSENBAUM, JAMES T · 2011 to 2020
$5.0M
Gene Expression Profiling in Granulomatosis with Polyangiitis and Related Conditions: Insights into Pathogenesis and Nonspecific CasesK23AR068440 · NIAMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SIBLEY, CAILIN H · 2015 to 2017
$469k
NEI NIH HHS EY020249NEI NIH HHS P30 EY 010572NEI NIH HHS P30 EY010572NEI NIH HHS R01 EY020249NIAMS NIH HHS K23 AR068440
6 · The paper itself

Abstract

The effort to subdivide diseases and to individualize therapies based on characteristics of the patient has been labeled precision medicine. Jameson and Longo define precision medicine as "treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations" (Jameson and Longo, 2015). We illustrate how molecular diagnosis can be applied to orbital inflammatory disease to achieve the goals of precision medicine.

Indexed as

BiopsyDiagnosis, DifferentialGene Expression ProfilingHumansMolecular Diagnostic TechniquesOphthalmologyOrbital DiseasesPrecision MedicineGranulomatosis with polyangiitisMolecular diagnosisNonspecific orbital inflammatory diseaseSarcoidosisThyroid eye diseaseTranscriptomics

Identifiers

PMID26608807
PMCPMC4912839

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.