Article in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
Endophenotype best practices.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017
Review
4 · The record
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
6 authors at 4 institutions in 1 country.
Trina M Norden-KrichmarDepartment of Molecular and Cellular Neuroscience,The Scripps Research Institute,La Jolla,CA,USA.
Ian R GizerDepartment of Psychological Sciences,University of Missouri,Columbia,MO,USA.
Evelyn PhillipsDepartment of Molecular and Cellular Neuroscience,The Scripps Research Institute,La Jolla,CA,USA.
Kirk C WilhelmsenDepartment of Genetics and Neurology,University of North Carolina,Chapel Hill,N.C.,USA.
Nicholas J SchorkDepartment of Human Biology,J. Craig Venter Institute,La Jolla,CA,USA.
Cindy L EhlersDepartment of Molecular and Cellular Neuroscience,The Scripps Research Institute,La Jolla,CA,USA.
Scripps Research Institute · USJ. Craig Venter Institute · USUniversity of Missouri · USUniversity of North Carolina at Chapel Hill · US
Funding
Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI JODI A LAPIDUS · 2004 to 2026
$102.6M
Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ERIC P ZORRILLA · 2003 to 2026
$46.3M
Quantitative Biology CoreU19AI063603 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI SCHORK, NICHOLAS JOSEPH · 2004 to 2015
$26.4M
Deep sequencing studies for cannabis and stimulant dependenceR01DA030976 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EHLERS, CINDY L, GELERNTER, JOEL · 2010 to 2014
$16.5M
SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE (UL1)UL1RR025774 · NCRR · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2008 to 2011
$16.3M
Substance Abuse & Behavioral Disinhibition: Integrating Genes & EnvironmentU01DA024417 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2007 to 2010
$10.8M
STATISTICS AND DATA MANAGEMENT COREP01AG027734 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI BARZILAI, NIR J · 2007 to 2012
$9.3M
RISK FACTORS FOR ALCOHOLISM IN NATIVE AMERICANSR37AA010201 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI EHLERS, CINDY L · 2007 to 2015
$7.0M
SYSTEMIC NEUROPHARMACOLOGYP50AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE · PI KOOB, GEORGE F · 1985 to 2002
$5.1M
Genome Wide Association of Coronary Artery Disease and Related Risk FactorsR01HL089655 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI BROECKEL, ULRICH · 2008 to 2012
$3.8M
Genomic Predictors of Combat Stress Vulnerability and ResilienceR01MH093500 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIEVERGELT, CAROLINE M · 2011 to 2013
$2.7M
Allele-specific Mapping in Alzheimer's DiseaseR01AG035020 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, TYCKO, BENJAMIN · 2010 to 2014
Neurophysiological measurements of the response to pre-pulse and startle stimuli have been suggested to represent an important endophenotype for both substance dependence and other select psychiatric disorders. We have previously shown, in young adult Mexican Americans (MA), that presentation of a short delay acoustic pre-pulse, prior to the startle stimuli can elicit a late negative component at about 400 msec (N4S), in the event-related potential (ERP), recorded from frontal cortical areas. In the present study, we investigated whether genetic factors associated with this endophenotype could be identified. The study included 420 (age 18-30 years) MA men (n = 170), and women (n = 250). DNA was genotyped using an Affymetrix Axiom Exome1A chip. An association analysis revealed that the CCKAR and CCKBR (cholecystokinin A and B receptor) genes each had a nearby variant that showed suggestive significance with the amplitude of the N4S component to pre-pulse stimuli. The neurotransmitter cholecystokinin (CCK), along with its receptors, CCKAR and CCKBR, have been previously associated with psychiatric disorders, suggesting that variants near these genes may play a role in the pre-pulse/startle response in this cohort.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Variants Near CCK Receptors are Associated With Electrophysiological Responses to Pre-pulse Startle Stimuli in a Mexican American Cohort. · full record | OpenQuestion