Trial reportBMC cancer2015
The effect of direct access to CT scan in early lung cancer detection: an unblinded, cluster-randomised trial.
Trial report in BMC cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01527214 (The Effect of Direct Referral for Fast CT Scan in Early Lung Cancer Detection in General Practice. Clinical, Randomised Trial), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Direct Referral for Fast CT Scan in Early Lung Cancer Detection in General Practice. Clinical, Randomised Trial
Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of interventions to recognise, refer and diagnose patients with lung cancer symptoms.NPJ primary care respiratory medicine · 2022Pooled it
- Impact of low-dose computed tomography (LDCT) screening on lung cancer-related mortality.The Cochrane database of systematic reviews · 2022Pooled it
- Immediate chest X-ray for patients at risk of lung cancer presenting in primary care: randomised controlled feasibility trial.British journal of cancer · 2017Trial
- Use of Open-Source Large Language Models for Automatic Synthesis of the Entire Imaging Medical Records of Patients: A Feasibility Study.Tomography (Ann Arbor, Mich.) · 2025Article
- Article
- Article
- Increased use of diagnostic CT imaging increases the detection of stage IA lung cancer: pathways and patient characteristics.BMC cancer · 2022Article
- Improving early diagnosis of symptomatic cancer.Nature reviews. Clinical oncology · 2016Review
- Family physician access to and wait times for cancer diagnostic investigations: Regional differences among 3 provinces.Canadian family physician Medecin de famille canadien · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLower lung cancer survival rates in Britain and Denmark compared with surrounding countries may, in part, be due to late diagnosis. The aim of this study was to evaluate the effect of direct access to low-dose computed tomography (LDCT) from general practice in early lung cancer detection on time to diagnosis and stage at diagnosis.
methodsWe conducted a cluster-randomised, controlled trial including all incident lung cancer patients (in 19-month period) listed with general practice in the municipality of Aarhus (300,000 citizens), Denmark. Randomisation and intervention were applied at general practice level. A total of 266 GPs from 119 general practices. In the study period, 331 lung cancer patients were included. The intervention included direct access to low-dose CT from primary care combined with a 1 h lung cancer update meeting. Indication for LDCT was symptoms or signs that raised the GP's suspicion of lung cancer, but fell short of satisfying the fast-track referral criteria on red flag' symptoms.
resultsThe intervention did not significantly influence stage at diagnosis and had limited impact on time to diagnosis. However, when correcting for non-compliance, we found that the patients were at higher risk of experiencing a long diagnostic interval if their GPs were in the control group.
conclusionDirect low-dose CT from primary care did not statistically significantly decrease time to diagnosis or change stage at diagnosis in lung cancer patients. Case finding with direct access to LDCT may be an alternative to lung cancer screening. Furthermore, a recommendation of low-dose CT screening should consider offering symptomatic, unscreened patients an access to CT directly from primary care.
trial registrationwww.clinicaltrials.gov, registration ID number NCT01527214.
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