Evidence map›Paper›PMID 26608649›Full record

Trial reportNutrition journal2015

Weight loss therapy for clinical management of patients with some atherosclerotic diseases: a randomized clinical trial.

Kuat Oshakbayev, Bibazhar Dukenbayeva, Nurzhan Otarbayev, Gulnar Togizbayeva, Nariman Tabynbayev, Meruyert Gazaliyeva, Alisher Idrisov, Pernekul Oshakbayev

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01700075 (Comparative Physical and Chemical Study of the Mechanisms of Atherosclerosis With Development of Concept of Treatment and Prevention), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01700075 phase4completednot on this map

Comparative Physical and Chemical Study of the Mechanisms of Atherosclerosis With Development of Concept of Treatment and Prevention

TypeinterventionalSponsorNazarbayev UniversityRan2009 to 2011Enrolled97ConditionsMyocardial Infarction, Coronary Artery Diseases, Diabetes Mellitus, Type 2, Atherosclerosis of Femoral ArteryArmsConventional treatment, Weight loss treatment
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kuat OshakbayevDepartment of metabolic syndrome, National Medical Holding, Astana, Kazakhstan. okp.kuat@mail.ru.
Bibazhar DukenbayevaFaculty of pathology and forensic medicine, Medical University Astana, Astana, Kazakhstan. dukenbaeva74@mail.ru.
Nurzhan OtarbayevDepartment of cardiology, National Medical Holding, Astana, Kazakhstan. otarbaev@rambler.ru.
Gulnar TogizbayevaFaculty of cardiology, Medical University Astana, Astana, Kazakhstan. gulnar1.01@mail.ru.
Nariman TabynbayevDepartment of science and education, National Medical Holding, Astana, Kazakhstan. nariman_tab@mail.ru.
Meruyert GazaliyevaFaculty of internal medicine, Karaganda State Medical University, Karaganda, Kazakhstan. gazaliyeva@yandex.ru.
Alisher IdrisovFaculty of endocrinology, Medical University Astana, Astana, Kazakhstan. aliser73@mail.ru.
Pernekul OshakbayevDepartment of science and innovations, Medical University Astana, Astana, Kazakhstan. o.peru@mail.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence and burden of atherosclerotic (AS) diseases are increasing during the last twenty years. Some studies show a close relationship between overweight and AS, but influence on AS diseases of different weight loss methods are still studying. The purpose of the research was to study the effectiveness of a weight loss program in AS patients in randomized controlled trial, and to develop a conception of evolution of AS.

methodsA randomized controlled prospective clinical trial including 97 people, from them 71 patients with various AS manifestations. Patients were divided in 2 subgroups for non-drug weight loss program, and conventional drug therapy. The weight loss program included calorie restriction with 100-150 kcal/day, fat-free vegetables, salt diet, and optimum physical activity. Statistical analysis was performed using SPSS for Windows version 17.0.

resultsThe weight loss subgroup lost ranging between 7-20% from an initial weight (P = 0.016). Weight loss was achieved due to fatty mass reduction only (P = 0.005). Hemoglobin levels (P < 0.001), bone mineral density (P < 0.001), percentages of water (P = 0.006) and muscle masses (P = 0.0038) were increased in weight loss subgroup. Ejection fraction (P < 0.0001), systolic output (P < 0.0001) were increased in patients with coronary artery disease. The weight loss program led to a decrease in symptomatic drugs doses up to total abolition. A conception of AS was developed.

conclusionsThe weight loss program treated the AS diseases; improved laboratory and instrumental parameters, decreased symptomatic drugs doses. AS development is a logical way of ontogenetic ageing of body fat. TRIAL INTERNATIONAL REGISTRATION: ClinicalTrials.gov NCT01700075. TRIAL NATIONAL REGISTRATION: State registration is # 0109RK000079, code is O.0475 at the National Center for Scientific and Technical Information of the Republic of Kazakhstan.

Indexed as

Weight LossAdultAgedAged, 80 and overAtherosclerosisCaloric RestrictionDiet, Fat-RestrictedExerciseFemaleHumansMaleMiddle AgedOverweightProspective StudiesTreatment OutcomeWalking

Identifiers

PMID26608649
PMCPMC4660604

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.