ArticleBMC research notes2015
Association between the rs12255372 variant of the TCF7L2 gene and obesity in a Cameroonian population.
Article in BMC research notes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 14 citations in OpenAlex.
- A Genetic Clue to T2DM in Bangladesh: TheOman medical journal · 2025Article
- Interaction between theFrontiers in nutrition · 2025Article
- Transcription factor 7-like 2 gene- smoking interaction on the risk of diabetic nephropathy in Chinese Han population.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021Article
- Non-communicable diseases pandemic and precision medicine: Is Africa ready?EBioMedicine · 2021Review
- Associations of TCF7L2 rs11196218 (A/G) and GLP-1R rs761386 (C/T) Gene Polymorphisms with Obesity in Chinese Population.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- A Nutrigenetic Approach to Investigate the Relationship between Metabolic Traits and Vitamin D Status in an Asian Indian Population.Nutrients · 2020Article
- Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism.Molecular metabolism · 2019Article
- Associations of TCF7L2 gene polymorphisms with the risk of diabetic nephropathy: A case-control study.Medicine · 2018Article
- The genomic landscape of African populations in health and disease.Human molecular genetics · 2017Review
- Article
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe transcription factor 7-like 2 (TCF7L2) is one of the genes that have been identified as possible determinants of diabetes which is associated with obesity. Data on the genetic causes of obesity in sub-Saharan African populations are very scares. The aim of this study was to assess the association between the transcription factor 7-like 2 (TCF7L2) gene polymorphism (rs12255372 G/T) and obesity and weight-related traits in a Cameroonian population.
methodsA case-control study was conducted on 35 obese and 30 non-obese Cameroonian adults. TCF7L2 rs12255372 genotypes were determined using PCR-RFLP and correlated with BMI and weight-related traits.
resultsNo significant association was observed between the rs12255372 T allele (χ(2) = 0.0684, p = 0.79) or the TT genotype (χ(2) = 0.372, p = 0.54) of the TCF7L2 gene and obesity in the Cameroonian population. However, amongst the weight-related traits, triglycerides were significantly associated with the T risk allele of the TCF7L2 gene (p = 0.012).
conclusionThis study on Cameroonian subjects replicates the absence of association between the TCF7L2 rs12255372 variant and obesity as observed in European and American populations.
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