ReviewJournal of dental research2016
Regenerative Medicine for Periodontal and Peri-implant Diseases.
Review in Journal of dental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
125 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Efficacy of stem cells in bone rehabilitation in patients with alveolar bone atrophy: a systematic review.Medicina oral, patologia oral y cirugia bucal · 2023Pooled it
- Growth Factors in Oral Tissue Engineering: New Perspectives and Current Therapeutic Options.BioMed research international · 2021Pooled it
- Efficacy of growth factors for the treatment of peri-implant diseases: a systematic review and meta-analysis.Clinical oral investigations · 2020Pooled it
- Apical approach in periodontal reconstructive surgery with enamel matrix derivate and enamel matrix derivate plus bone substitutes: a randomized, controlled clinical trial.Clinical oral investigations · 2022Trial
- Review
- Emerging, personalized, and minimally invasive technologies for periodontal and peri-implant soft and hard tissue regenerative therapy.Journal of periodontology · 2026Review
- New technologies in oral reconstructive medicine: Consensus report of the AAP/OF/SEPA Workshop.Journal of periodontology · 2026Article
- 3D-Bioprinted Multifunctional Nanocomposite Scaffolds for Alveolar Bone-Periodontal Ligament-Root Cementum Regeneration: A Narrative Review.Biomimetics (Basel, Switzerland) · 2026Review
- Core-shell microneedles Co-loaded with simvastatin and doxycycline for combined anti-infection and osteogenesis in diabetic periodontitis.Materials today. Bio · 2026Article
- Nanoparticle-integrated smart hydrogel with HJournal of nanobiotechnology · 2026Article
- Comparison of physical, mechanical and biological properties of a porcine urinary bladder acellular matrix collagen membrane with six other collagen membranes of animal origin.BMC oral health · 2026Article
- Timing of Dental Implant Placement: The Past, the Present, the Future.Journal of periodontal research · 2026Review
- Transcriptomic characterization of platelet-rich fibrin-induced macrophage responses identifies U937 cells as a sensitive bioassay.Frontiers in immunology · 2026Article
- A neurovascularized bone regeneration strategy for mandibular and alveolar bone defects based on elastin-like biomaterials.Regenerative biomaterials · 2026Article
- Oxidative stress and antioxidant pathways in the pathogenesis of periodontitis and peri-implantitis: mechanistic insights and therapeutic potentials.Frontiers in oral health · 2026Review
- Rationalization Progress of Novel Drug Delivery System for Intra-periodontal Pockets Against Periodontitis.Pharmaceutical nanotechnology · 2026Review
- Three Decades of Prosthodontic Oral Rehabilitation: A Bibliometric Analysis of Materials, Implants, and Digital Workflows.International journal of dentistry · 2026Review
- Comparative Evaluation of Hyaluronic Acid (hyaDENT BGJournal of functional biomaterials · 2025Article
- Bioengineering of Periodontal Tissues: Cell Therapy and Biomaterials Application.Bioengineering (Basel, Switzerland) · 2025Review
- Effects of Caffeine on Dental Mesenchymal Stem Cells: Implications for Regenerative Applications.Journal of functional biomaterials · 2025Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The balance between bone resorption and bone formation is vital for maintenance and regeneration of alveolar bone and supporting structures around teeth and dental implants. Tissue regeneration in the oral cavity is regulated by multiple cell types, signaling mechanisms, and matrix interactions. A goal for periodontal tissue engineering/regenerative medicine is to restore oral soft and hard tissues through cell, scaffold, and/or signaling approaches to functional and aesthetic oral tissues. Bony defects in the oral cavity can vary significantly, ranging from smaller intrabony lesions resulting from periodontal or peri-implant diseases to large osseous defects that extend through the jaws as a result of trauma, tumor resection, or congenital defects. The disparity in size and location of these alveolar defects is compounded further by patient-specific and environmental factors that contribute to the challenges in periodontal regeneration, peri-implant tissue regeneration, and alveolar ridge reconstruction. Efforts have been made over the last few decades to produce reliable and predictable methods to stimulate bone regeneration in alveolar bone defects. Tissue engineering/regenerative medicine provide new avenues to enhance tissue regeneration by introducing bioactive models or constructing patient-specific substitutes. This review presents an overview of therapies (e.g., protein, gene, and cell based) and biomaterials (e.g., resorbable, nonresorbable, and 3-dimensionally printed) used for alveolar bone engineering around teeth and implants and for implant site development, with emphasis on most recent findings and future directions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.