Evidence map›Paper›PMID 26608545›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2015

Prognostic utility of cardiovascular magnetic resonance upright maximal treadmill exercise testing.

Bunyapon Sukpraphrute, Brandon C Drafts, Pairoj Rerkpattanapipat, Timothy M Morgan, Paul M Kirkman, William O Ntim, Craig A Hamilton, Robert L Cockrum, W Gregory Hundley

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Exercise cardiac magnetic resonance imaging: a feasibility study and meta-analysis.American journal of physiology. Regulatory, integrative and comparative physiology · 2018
    Pooled it
  2. Quantitative myocardial blood flow and perfusion reserve with exercise cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Exercise cardiovascular magnetic resonance: development, current utility and future applications.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020
    Review
  7. Article
  8. Review
  9. Review of Journal of Cardiovascular Magnetic Resonance (JCMR) 2015-2016 and transition of the JCMR office to Boston.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017
    Review
  10. Review
  11. Review of Journal of Cardiovascular Magnetic Resonance 2015.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2016
    Review
  12. Observational
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Bunyapon SukpraphruteDepartments of Internal Medicine (Cardiovascular Medicine Section), Wake Forest Health Sciences, Medical Center Boulevard, Winston-Salem, North Carolina, NC 27157-1045, USA. dd992@hotmail.com.
Brandon C DraftsDepartments of Internal Medicine (Cardiovascular Medicine Section), Wake Forest Health Sciences, Medical Center Boulevard, Winston-Salem, North Carolina, NC 27157-1045, USA. bdrafts@wakehealth.edu.
Pairoj RerkpattanapipatFrye Heart Center, Hickory, North Carolina, USA. aemc@hotmail.com.
Timothy M MorganPublic Health Sciences, Wake Forest Health Sciences, Winston-Salem, North Carolina, USA. tomorgan@wakehealth.edu.
Paul M KirkmanDepartments of Internal Medicine (Cardiovascular Medicine Section), Wake Forest Health Sciences, Medical Center Boulevard, Winston-Salem, North Carolina, NC 27157-1045, USA. pkirkman@wakehealth.edu.
William O NtimMid Carolina Cardiology, Charlotte, North Carolina, USA. wntim@novanthealth.org.
Craig A HamiltonBiomedical Engineering, Wake Forest Health Sciences, Winston-Salem, North Carolina, USA. crhamilt@wakhealth.edu.
Robert L CockrumDepartments of Internal Medicine (Cardiovascular Medicine Section), Wake Forest Health Sciences, Medical Center Boulevard, Winston-Salem, North Carolina, NC 27157-1045, USA. rcockrum@wakhealth.edu.
W Gregory HundleyDepartments of Internal Medicine (Cardiovascular Medicine Section), Wake Forest Health Sciences, Medical Center Boulevard, Winston-Salem, North Carolina, NC 27157-1045, USA. ghundley@wakehealth.edu.
Wake Forest University · US

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUNDLEY, WILLIAM GREGORY · 1992 to 2010
$35.2M
NCRR NIH HHS 3 M01 RR07122-08S1NCRR NIH HHS M01 RR007122NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG21332PHS HHS M01 RF071225
6 · The paper itself

Abstract

backgroundLeft ventricular wall motion abnormalities (LVWMA) observed during cardiovascular magnetic resonance (CMR) pharmacologic stress testing can be used to determine cardiac prognosis, but currently, information regarding the prognostic utility of upright maximal treadmill induced LVWMA is unknown. Our objective was to determine the prognostic utility of upright maximal treadmill exercise stress CMR.

methodsOne hundred and fifteen (115) men and women with known or suspected coronary arteriosclerosis and an appropriate indication for cardiovascular (CV) imaging to supplement ST segment stress testing underwent an upright treadmill exercise CMR stress test in which LVWMA were identified before and immediately after exercise. Personnel blinded to results determined the post-test incidence of cardiac events (cardiac death, myocardial infarctions [MI], and unstable angina warranting hospital admission or coronary arterial revascularization).

resultsAll participants completed the testing protocol, with 90% completing image acquisition within 60 s of exercise cessation. MI or cardiac death occurred in 3% of individuals without and 17% of individuals with inducible LVWMA (p = 0.024). The combination of MI, cardiac death, and unstable angina warranting hospitalization occurred in 14% of individuals without and 47% of individuals with inducible LVWMA (p = 0.002). The addition of CMR imaging identified those at risk for future events (p = 0.002), as opposed to the electrocardiogram stress test alone (p = 0.63).

conclusionsIn patients with or suspected of coronary arteriosclerosis and appropriate indication for imaging to supplement ST segment analysis during upright treadmill exercise, the presence of inducible LVWMA during treadmill exercise stress CMR supplements ST segment monitoring and helps identify those at risk of the future combined endpoints of myocardial infarction, cardiac death, and unstable angina warranting hospitalization.

Indexed as

Magnetic Resonance ImagingMyocardial ContractionPatient PositioningVentricular Function, LeftAdultAgedAngina, UnstableCoronary Artery DiseaseExercise TestFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionPredictive Value of Tests

Identifiers

PMID26608545
PMCPMC4660781
OpenAlexW2180150690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.