Evidence map›Paper›PMID 26608342›Full record

Trial reportBMC pregnancy and childbirth2015

Use of mouth rinse during pregnancy to improve birth and neonatal outcomes: a randomized controlled trial.

Hong Jiang, Xu Xiong, Pierre Buekens, Yi Su, Xu Qian

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pregnancy and childbirth, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04140643 (Ozone Therapy as an Aid for Home Oral Hygiene. The Use of Aquolab in the Pregnant Woman.), which is not on this map. Cited by 9 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 5 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04140643 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Ozone Therapy as an Aid for Home Oral Hygiene. The Use of Aquolab in the Pregnant Woman.

TypeinterventionalSponsorIRCCS San RaffaeleRan2019 to 2020Enrolled60ConditionsPregnancy Gingivitis, OzoneArmsOzonated water delivering device effects on the oral health of pregnant women, Oral hygiene instructions
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 5 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Hong JiangSchool of Public Health; Global Health Institute, Fudan University, Mailbox 175, No. 138 Yixueyuan Road, Shanghai, 200032, China. h_jiang@fudan.edu.cn.
Xu XiongSchool of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 2022, New Orleans, LA, 70112, USA. xxiong@tulane.edu.
Pierre BuekensSchool of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 2022, New Orleans, LA, 70112, USA. pbuekens@tulane.edu.
Yi SuEye & ENT Hospital of Fudan University, Shanghai, China. suyitianjin@aliyun.com.
Xu QianSchool of Public Health; Global Health Institute, Fudan University, Mailbox 175, No. 138 Yixueyuan Road, Shanghai, 200032, China. xqian@fudan.edu.cn.
Fudan University · CNTulane University · USEye & ENT Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPoor oral health, such as periodontal (gum) disease, has been found to be associated with an increased risk of adverse pregnancy outcomes including preterm birth, low birth weight, and neonatal and infant mortality, especially in low-and middle-income countries. However, there is little or no access to preventive dental care in most low-and middle-income countries. We propose to develop and test a "Mouth Rinse Intervention" among pregnant women to prevent the progression of periodontal disease during pregnancy and reduce adverse birth and neonatal outcomes in a rural county of China. METHODS/

designThis is a randomized controlled clinical trial. A sample of 468 (234 in each arm of the study) women in early pregnancy with periodontal disease will be recruited for the study. Periodontal disease will be diagnosed through the methods of Periodontal Screening and Recording. All women diagnosed with periodontal disease will be randomly allocated into the intervention or control group. Women assigned in the intervention group will be provided with non-alcohol antimicrobial mouth rinse containing cetylpyridinium chloride throughout the pregnancy and oral health education. Women in the control group will receive a package of tooth brush and paste, plus oral hygiene education. Women will be followed-up to childbirth until the 42nd day postpartum. The main outcomes include mean birthweight (gram) and mean gestational age (week). DISCUSSION: Compared with conventional mechanical 'scaling and root planning' periodontal treatment during pregnancy, our proposed mouth rinse intervention could be a simple, cost-effective, and sustainable solution to improve both mother's oral health and neonate outcomes. If the mouth rinse is confirmed to be effective, it would demonstrate great potential for the application in other low- or middle-income countries to prevent adverse birth outcomes such as preterm birth and low birth weight and to reduce neonatal and infant mortality.

trial registrationThis trial was registered with Chinese Clinical Trial Registry (ChiCTR): ( #ChiCTR-TRC-13003768 ) on November 06, 2013.

Indexed as

Pregnancy OutcomeAdolescentAdultAnti-Infective Agents, LocalBirth WeightCetylpyridiniumChinaFemaleGestational AgeHumansInfantInfant MortalityInfant, NewbornMouthwashesOral HealthPeriodontal DiseasesAnti-Infective Agents, LocalCetylpyridiniumMouthwashes

Identifiers

PMID26608342
PMCPMC4660817
OpenAlexW2172686504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.