ArticleMedical hypotheses2016
Seasonality and selective trends in viral acute respiratory tract infections.
Article in Medical hypotheses, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06531707 (Efficacy and Safety of Ibuprofen/Loratadine Fixed-dose Combination Versus the Fixed-dose Administration of Monotherapy as Symptomatic Treatment for Patients With the Common Cold), which is not on this map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of Ibuprofen/Loratadine Fixed-dose Combination Versus the Fixed-dose Administration of Monotherapy as Symptomatic Treatment for Patients With the Common Cold
Who cites it
38 citing papers in PubMed, 80 citations in OpenAlex.
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- Characterisation of the respiratory syncytial virus seasonality and its environmental factors in the Americas-a multi-country observational study using routine surveillance networks.Lancet regional health. Americas · 2025Article
- Population-level respiratory virus-virus interactions, Puerto Rico, 2013-2023.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025Article
- Herbal Medicine in Acute and Chronic Sinusitis; Still a Cinderella?Current allergy and asthma reports · 2025Review
- Scoping review on assessing climate-sensitive health risks.BMC public health · 2025Article
- Retrospective study on the epidemiological characteristics of multi-pathogen infections of hospitalized severe acute respiratory tract infection and influenza-like illness in Xinjiang from January to May 2024.BMC infectious diseases · 2025Article
- Analysis of Drug-Resistant Bacteria Seasonality in Japan Using Financial Time Series Analysis Method: A Nationwide Longitudinal Study.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Article
- Will COVID-19 become mild, like a cold?Epidemiology and infection · 2024Review
- Article
- Air Pollution and Influenza: A Systematic Review and Meta-Analysis.Iranian journal of public health · 2024Review
- A combination of annual and nonannual forces drive respiratory disease in the tropics.medRxiv : the preprint server for health sciences · 2023Article
- The Impact of Cold Ambient Temperature in the Pattern of Influenza Virus Infection.Open forum infectious diseases · 2023Article
- The natural thermal sensitivity of SARS-CoV-2.Infectious medicine · 2022Article
- Meteorological factors' effects on COVID-19 show seasonality and spatiality in Brazil.Environmental research · 2022Article
- Combinatorial influence of environmental temperature, obesity and cholesterol on SARS-CoV-2 infectivity.Scientific reports · 2022Article
- Effects of particulate matter on hospital admissions for respiratory diseases: an ecological study based on 12.5 years of time series data in Shanghai.Environmental health : a global access science source · 2022Article
- The effects of indoor temperature and humidity on local transmission of COVID-19 and how it relates to global trends.PloS one · 2022Article
- Temperature dependent viral tropism: understanding viral seasonality and pathogenicity as applied to the avoidance and treatment of endemic viral respiratory illnesses.Reviews in medical virology · 2022Review
- Assessing the impact of air pollution and climate seasonality on COVID-19 multiwaves in Madrid, Spain.Environmental research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Influenza A and B, and many unrelated viruses including rhinovirus, RSV, adenovirus, metapneumovirus and coronavirus share the same seasonality, since these viral acute respiratory tract infections (vARIs) are much more common in winter than summer. Unfortunately, early investigations that used recycled "pedigree" virus strains seem to have led microbiologists to dismiss the common folk belief that vARIs often follow chilling. Today, incontrovertible evidence shows that ambient temperature dips and host chilling increase the incidence and severity of vARIs. This review considers four possible mechanisms, M1 - 4, that can explain this link: (M1) increased crowding in winter may enhance viral transmission; (M2) lower temperatures may increase the stability of virions outside the body; (M3) chilling may increase host susceptibility; (M4) lower temperatures or host chilling may activate dormant virions. There is little evidence for M1 or M2, which are incompatible with tropical observations. Epidemiological anomalies such as the repeated simultaneous arrival of vARIs over wide geographical areas, the rapid cessation of influenza epidemics, and the low attack rate of influenza within families are compatible with M4, but not M3 (in its simple form). M4 seems to be the main driver of seasonality, but M3 may also play an important role.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.