SynthesisAIDS care2015
Are couple-based interventions more effective than interventions delivered to individuals in promoting HIV protective behaviors? A meta-analysis.
Synthesis in AIDS care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03809364 (Supporting Treatment for Anti-Retroviral Therapy), which is not on this map. Cited by 60 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Supporting Treatment for Anti-Retroviral Therapy (START) Together: Development of a Couple-based Medication Adherence Intervention for HIV-positive Women and Their Male Partners in Sweetwaters, South Africa
Who cites it
60 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Strategies to increase couples HIV testing and counselling in sub-Saharan Africa: a systematic review.Journal of the International AIDS Society · 2023Pooled it
- Do Couple-Based Interventions Show Larger Effects in Promoting HIV Preventive Behaviors than Individualized Interventions in Couples? A Systematic Review and Meta-analysis of 11 Randomized Controlled Trials.AIDS and behavior · 2023Pooled it
- Couples-based interventions and postpartum contraceptive uptake: A systematic review.Contraception · 2022Pooled it
- Dyadic Interdependence in Non-spousal Caregiving Dyads' Wellbeing: A Systematic Review.Frontiers in psychology · 2022Pooled it
- A Mixed-Methods Systematic Review: Infidelity, Romantic Jealousy and Intimate Partner Violence against Women.International journal of environmental research and public health · 2020Pooled it
- Research Synthesis, HIV Prevention Response, and Public Health: CDC's HIV/AIDS Prevention Research Synthesis Project.Public health reports (Washington, D.C. : 1974)Pooled it
- Effectiveness of interventions to promote couples-based HIV testing and family health during pregnancy and postpartum in Kenya: a multicentre, couples-based, randomised controlled trial.The lancet. HIV · 2026Trial
- Randomized Controlled Trial of a Couples-Based HIV Intervention for Transgender Women and Their Partners: Findings from the "It Takes Two" Project.AIDS and behavior · 2025Trial
- A Relationship-Focused HIV Prevention Intervention for Young Sexual Minority Men in the United States: A Pilot Randomized Controlled Trial of the We Prevent Intervention.AIDS and behavior · 2023Trial
- Social Influence and Uptake of Couples HIV Testing and Counselling in KwaZulu-Natal, South Africa.AIDS and behavior · 2022Trial
- The Influence of Relationship Dynamics and Sexual Agreements on Perceived Partner Support and Benefit of PrEP Use Among Same-Sex Male Couples in the U.S.AIDS and behavior · 2020Trial
- Pathways for HIV Prevention Behaviors Following a Home-Based Couples Intervention for Pregnant Women and Male Partners in Kenya.AIDS and behavior · 2020Trial
- Predicting organizational readiness to implement HIV prevention with couples using practitioners' intentions: testing a heuristic.Translational behavioral medicine · 2020Trial
- Results of a Couples-Based Randomized Controlled Trial Aimed to Increase Testing for HIV.Journal of acquired immune deficiency syndromes (1999) · 2019Trial
- Changing sex risk behaviors, gender norms, and relationship dynamics among couples in Cape Town, South Africa: Efficacy of an intervention on the dyad.Social science & medicine (1982) · 2018Trial
- Assisted partner notification services are cost-effective for decreasing HIV burden in western Kenya.AIDS (London, England) · 2018Trial
- Couple-Based Intervention to Improve HIV Care Engagement for Women and their Partners in KwaZulu-Natal, South Africa: Outcomes of a Pilot Randomized Controlled Trial.Journal of the International Association of Providers of AIDS CareTrial
- Article
- Compendium of dyadic behavior change techniques v2.0: results from a Delphi study.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- Together we win! Narratives of couples pursuing a healthy diet and physical activity: A qualitative study.Health science reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Despite several advantages to bringing couples together to learn how to protect themselves and new-born children from the risk of HIV infection, most interventions are designed for individuals or groups, not for dyads. This meta-analysis provides a direct test of whether couple-based interventions are more effective in promoting HIV protective behaviors than interventions delivered to individuals. We conducted systematic searches of five electronic databases and 60 journals. Eligible studies were controlled trials or prospective cohort designs; evaluated a couple-based intervention compared to an individual-level intervention; assessed at least one HIV prevention outcome (e.g., protective sex, drug use, HIV testing, medication adherence, and sexually transmitted infections [STI]); and were published between 1988 and 2014. Fifteen interventions, including 21,882 participants from China, Kenya, Rwanda, Tanzania, Trinidad, Zambia, and the USA, were evaluated. The results of random-effects models showed statistically significant intervention effects for protective sex (OR = 1.60, 95% CI = 1.21, 2.11), HIV testing (OR = 1.79, 95% CI = 1.31, 2.45), and Nevirapine uptake (OR = 1.51, 95% CI = 1.02, 2.24). The evidence demonstrates the usefulness of couple-based interventions in protecting individuals, partners, and new-born children from the risk of HIV transmission and infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.