ArticleBMC pregnancy and childbirth2015
Medication use during pregnancy, gestational age and date of delivery: agreement between maternal self-reports and health database information in a cohort.
Article in BMC pregnancy and childbirth, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Estimating the Prevalence of Prescribed Medication Use in Pregnancy with a Systematic Review and Meta-analysis.Drug safety · 2026Pooled it
- Prevalence and associated factors of self-medication in worldwide pregnant women: systematic review and meta-analysis.BMC public health · 2024Pooled it
- Prevalence of systemic antibacterial use during pregnancy worldwide: A systematic review.PloS one · 2024Pooled it
- Reliability of Self-Reported Maternal Health and Mother-Infant Outcome Data in Web-Based Questionnaires.Drug safety · 2026Article
- Reducing Exposure Before Birth: An Interrupted Time Series Study of Prenatal Exposure to Fetotoxic Medications Under Risk Management Plans in Canada.Clinical pharmacology and therapeutics · 2026Article
- Concordance of Self-Reported Obstetric Outcomes With Electronic Health Record Documentation: A Secondary Analysis of the Nulliparous Pregnancy Outcomes Study Monitoring Mothers-To-Be.Birth (Berkeley, Calif.) · 2025Article
- Medication use from conception to the first antenatal appointment: agreement between maternal self-report to midwife and prescribing records in Northern Ireland in 2011-2016.International journal of population data science · 2025Article
- Reduce, reinforce, and replenish: safeguarding the early-life microbiota to reduce intergenerational health disparities.Frontiers in public health · 2024Review
- Agreement between Patient-reported Pain Medication Use and Electronic Medical Record Data in Surgical Amputation Patients.Plastic and reconstructive surgery. Global open · 2023Article
- Patterns of Prescription Medication Use during the First Trimester of Pregnancy in the United States, 1997-2018.Clinical pharmacology and therapeutics · 2023Article
- Maternal infections and medications in pregnancy: how does self-report compare to medical records in childhood cancer case-control studies?International journal of epidemiology · 2023Article
- Agreement between maternal report and medical records on use of medications during early pregnancy in New York.Birth defects research · 2023Article
- Determining antenatal medicine exposures in South African women: a comparison of three methods of ascertainment.BMC pregnancy and childbirth · 2022Article
- Adherence to treatment for hypothyroidism in pregnancy and relationship with thyrotropin control: a retrospective observational cohort study.BMC pregnancy and childbirth · 2022Observational
- Evaluation of the pregnant women's approaches regarding drug utilization.Northern clinics of Istanbul · 2021Article
- Interaction between Maternal Immune Activation and Antibiotic Use during Pregnancy and Child Risk of Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2020Article
- Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones.JAMA network open · 2020Article
- Quantification of selection bias in studies of risk factors for birth defects among livebirths.Paediatric and perinatal epidemiology · 2020Article
- Integration of Placental Transfer in a Fetal-Maternal Physiologically Based Pharmacokinetic Model to Characterize Acetaminophen Exposure and Metabolic Clearance in the Fetus.Clinical pharmacokinetics · 2020Article
- Psychiatric Disorders in the Adolescent Offspring of Mothers with Thyroid Problems During Pregnancy.Child psychiatry and human development · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHealth databases are a promising resource for epidemiological studies on medications safety during pregnancy. The reliability of information on medications exposure and pregnancy timing is a key methodological issue. This study (a) compared maternal self-reports and database information on medication use, gestational age, date of delivery; (b) quantified the degree of agreement between sources; (c) assessed predictors of agreement.
methodsPregnant women recruited in a prenatal clinic in Friuli Venezia Giulia (FVG) region, Italy, from 2007 to 2009, completed a questionnaire inquiring on medication use during pregnancy, gestational age and date of delivery. Redeemed prescriptions and birth certificate records were extracted from regional databases through record linkage. Percent agreement, Kappa coefficient, prevalence and bias-adjusted Kappa (PABAK) were calculated. Odds Ratio (OR), with 95% confidence interval (95% CI), of ≥ 1 agreement was calculated through unconditional logistic regression.
resultsThe cohort included 767 women, 39.8% reported medication use, and 70.5% were dispensed at least one medication. Kappa and PABAK indicated almost perfect to substantial agreement for antihypertensive medications (Kappa 0.86, PABAK 0.99), thyroid hormones (0.88, 0.98), antiepileptic medications (1.00, 1.00), antithrombotic agents (0.70, 0.96). PABAK value was greater than Kappa for medications such as insulin (Kappa 0.50, PABAK 0.99), antihistamines for systemic use (0.50, 0.99), progestogens (0.28, 0.79), and antibiotics (0.12, 0.63). Adjusted OR was 0.48 (95% CI 0.26; 0.90) in ex- vs. never smokers, 0.64 (0.38; 1.08) in < high school vs. university, 1.55 (1.01; 2.37) in women with comorbidities, 2.25 (1.19; 4.26) in those aged 40+ vs. 30-34 years. Gestational age matched exactly in 85.2% and date of delivery in 99.5%.
conclusionsFor selected medications used for chronic conditions, the agreement between self-reports and dispensing data was high. For medications with low to very low prevalence of use, PABAK provides a more reliable measure of agreement. Maternal reports and dispensing data are complementary to each other to increase the reliability of information on the use of medications during pregnancy. Birth certificates provide reliable data on the timing of pregnancy. FVG health databases are a valuable source of data for pregnancy research.
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