Evidence map›Paper›PMID 26607939›Full record

SynthesisThe American journal of clinical nutrition2016

Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study.

Melissa A Merritt, Ioanna Tzoulaki, Piet A van den Brandt, Leo J Schouten, Konstantinos K Tsilidis, Elisabete Weiderpass, Chirag J Patel, Anne Tjønneland, Louise Hansen, Kim Overvad and 36 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. CD36: The Bridge between Lipids and Tumors.Molecules (Basel, Switzerland) · 2024
    Review
  8. Integrative Medicine for Ovarian Cancer.Current oncology reports · 2023
    Review
  9. Review
  10. Article
  11. Prospective Analyses of Lifestyle Factors Related to Energy Balance and Ovarian Cancer Risk by Infiltration of Tumor-Associated Macrophages.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
  12. Article
  13. Review
  14. Review
  15. Adult dietary fat intake and ovarian cancer risk.International journal of cancer · 2020
    Article
  16. Article
  17. Review
  18. Article
  19. Is Ovarian Cancer Prevention Currently Still a recommendation of Our Grandparents?Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors at 20 institutions in 14 countries.

Melissa A MerrittDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; m.merritt@imperial.ac.uk.ORCID http://orcid.org/0000-0002-5067-6119
Ioanna TzoulakiDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom;
Piet A van den BrandtDepartment of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, Netherlands;
Leo J SchoutenDepartment of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, Netherlands;
Konstantinos K TsilidisDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece;
Elisabete WeiderpassDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø-The Arctic University of Norway, Tromsø, Norway; Department of Research, Cancer Registry of Norway, Oslo, Norway; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland;
Chirag J PatelDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA;
Anne TjønnelandDanish Cancer Society Research Center, Copenhagen, Denmark;
Louise HansenDanish Cancer Society Research Center, Copenhagen, Denmark;
Kim OvervadDepartment of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark;
Mathilde HisCentre for Research in Epidemiology and Population Health, Inserm (Institut National de la Santé et de la Recherche Médicale), Villejuif Cedex, France; Univ Paris Sud, Villejuif, France; Gustave Roussy, Villejuif, France;
Laureen DartoisCentre for Research in Epidemiology and Population Health, Inserm (Institut National de la Santé et de la Recherche Médicale), Villejuif Cedex, France; Univ Paris Sud, Villejuif, France; Gustave Roussy, Villejuif, France;
Marie-Christine Boutron-RuaultCentre for Research in Epidemiology and Population Health, Inserm (Institut National de la Santé et de la Recherche Médicale), Villejuif Cedex, France; Univ Paris Sud, Villejuif, France; Gustave Roussy, Villejuif, France;
Renée T FortnerDivision of Cancer Epidemiology, German Cancer Research Center [Deutsches Krebsforschungszentrum (DKFZ)], Heidelberg, Germany;
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center [Deutsches Krebsforschungszentrum (DKFZ)], Heidelberg, Germany;
Krasimira AleksandrovaDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany;
Heiner BoeingDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany;
Antonia TrichopoulouHellenic Health Foundation, Athens, Greece; Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece;
Pagona LagiouDepartment of Epidemiology, Harvard School of Public Health, Boston, MA; Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece;
Christina BamiaDepartment of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece;
Domenico PalliMolecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-Istituto per lo Studio e la Prevenzione Oncologica (ISPO), Florence, Italy;
Vittorio KroghEpidemiology and Prevention Unit, Fondazione Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori, Milano, Italy;
Rosario TuminoCancer Registry and Histopathology Unit, "Civic-M.P. Arezzo" Hospital, Azienda Sanitaria Provinciale, Ragusa, Italy;
Fulvio RicceriUnit of Epidemiology, Regional Health Service, Azienda Sanitaria Locale (ASL) TO3, Grugliasco, Italy; Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy;
Amalia MattielloDipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy;
H Bas Bueno-de-MesquitaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department for Determinants of Chronic Diseases, National Institute for Public Health and the Environment [Rijksinstituut voor Volksgezondheid en Milieu (RIVM)], Bilthoven, Netherlands; Department of Gastroenterology and Hepatology and Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;
N Charlotte Onland-MoretDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands;
Petra H PeetersDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands;
Guri SkeieDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø-The Arctic University of Norway, Tromsø, Norway;
Mie JareidDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø-The Arctic University of Norway, Tromsø, Norway;
J Ramón QuirósPublic Health Directorate, Asturias, Oviedo, Spain;
Mireia Obón-SantacanaUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (Institut Català d'Oncologia (ICO)-Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain;
María-José SánchezEscuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; CIBER de Epidemiología y Salud Pública, Madrid, Spain;
Saioa ChamosaPublic Health Division of Gipuzkoa, BioDonostia Research Institute, Health Department of Basque Region, San Sebastian, Spain;
José M HuertaCIBER de Epidemiología y Salud Pública, Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain;
Aurelio BarricarteCIBER de Epidemiología y Salud Pública, Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA) Pamplona, Spain;
Joana A DiasDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden;
Emily SonestedtDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden;
Annika IdahlDepartment of Clinical Sciences, Obstetrics and Gynecology, Department of Public Health and Clinical Medicine, Nutritional Research and.
Eva LundinDepartment of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden;
Nicholas J WarehamMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom;
Kay-Tee KhawCambridge Institute of Public Health, University of Cambridge, Cambridge, United Kingdom;
Ruth C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; and.
Pietro FerrariNutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France.
Elio RiboliDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom;
Marc J GunterDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom;
Imperial College London · GBInserm · FRDanish Cancer Society · DKGerman Cancer Research Center · DEGerman Institute of Human Nutrition · DEHarvard University · USLund University · SEMaastricht University · NLUiT The Arctic University of Norway · NOUniversity of Cambridge · GBAarhus University · DKAcademy of Athens · GRAzienda Sanitaria Locale Roma 3 · ITAzienda Usl 8 Arezzo · ITBasque Government · ESCentre international de recherche sur le cancer · FRFederico II University Hospital · ITGobierno del Principado de Asturias · ESInstitut d'Investigació Biomédica de Bellvitge · ESInstituto de Investigación Biosanitaria de Granada · ES

Funding

Data-driven identification of environmental factors in cardiovascular diseaseR00ES023504 · NIEHS · HARVARD MEDICAL SCHOOL · PI PATEL, CHIRAG J. · 2016 to 2018
$728k
Increasing the power of GxE detection by using multi-locus genome-wide predictorsR21ES025052 · NIEHS · HARVARD MEDICAL SCHOOL · PI PATEL, CHIRAG J. · 2015 to 2017
$434k
Data-driven identification of environmental factors in cardiovascular diseaseK99ES023504 · NIEHS · HARVARD MEDICAL SCHOOL · PI PATEL, CHIRAG J. · 2014 to 2015
$245k
Cancer Research UK 14136Cancer Research UK 16491Cancer Research UK C570/A16491Cancer Research UK C8221/A19170Medical Research Council 1000143Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MC_U106179471Medical Research Council MC_UU_12015/1Medical Research Council MR/M012190/1NIEHS NIH HHS K99 ES023504NIEHS NIH HHS R00 ES023504NIEHS NIH HHS R21 ES025052World Health Organization 001
6 · The paper itself

Abstract

backgroundStudies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk.

objectiveWe used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort.

designWe assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs.

resultsNone of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall HR: 1.21; 95% CI: 1.04, 1.41).

conclusionIn the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat.

Indexed as

Feeding BehaviorAdultAgedCarcinoma, Ovarian EpithelialCohort StudiesDietDietary FatsFatty AcidsFemaleHumansMaleMiddle AgedNeoplasms, Glandular and EpithelialNetherlandsOvarian NeoplasmsRisk FactorsDietary FatsFatty Acidsdietnutritionovarian cancerprospective cohortsaturated fatserous

Identifiers

PMID26607939
PMCPMC6459057
OpenAlexW2175796058

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.