Evidence map›Paper›PMID 26607935›Full record

ArticleThe American journal of clinical nutrition2016

Lipid-based nutrient supplements for pregnant women reduce newborn stunting in a cluster-randomized controlled effectiveness trial in Bangladesh.

Malay K Mridha, Susana L Matias, Camila M Chaparro, Rina R Paul, Sohrab Hussain, Stephen A Vosti, Kassandra L Harding, Joseph R Cummins, Louise T Day, Stacy L Saha and 2 more

Registry-linked trialOpen access · bronzeAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01715038 (Home-fortification Approaches for the Prevention of Malnutrition in Pregnant and Lactating Women and Their Children in Bangladesh), which is not on this map. Cited by 75 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 14 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01715038 nacompletednot on this map

Home-fortification Approaches for the Prevention of Malnutrition in Pregnant and Lactating Women and Their Children in Bangladesh: Program Effectiveness Study

TypeinterventionalSponsorUniversity of California, DavisRan2011 to 2015Enrolled4,011ConditionsMalnutritionArmsLNS-PLW, LNS-Child, MNP, IFA
3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 14 syntheses or guidelines pooled it, 131 citations in OpenAlex.

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  10. Multiple-micronutrient supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019
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  13. Multiple-micronutrient supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2017
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  14. Multiple-micronutrient supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2015
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Malay K MridhaDepartments of Nutrition and International Center for Diarrheal Disease Research, Dhaka, Bangladesh;
Susana L MatiasDepartments of Nutrition and.
Camila M ChaparroConsultant, Milton, MA; and.
Rina R PaulInternational Center for Diarrheal Disease Research, Dhaka, Bangladesh;
Sohrab HussainInternational Center for Diarrheal Disease Research, Dhaka, Bangladesh;
Stephen A VostiAgricultural and Resource Economics, University of California, Davis, Davis, CA;
Kassandra L HardingDepartments of Nutrition and.
Joseph R CumminsDepartment of Economics, University of California, Riverside, Riverside, CA;
Louise T DayLAMB, Dinajpur, Bangladesh.
Stacy L SahaLAMB, Dinajpur, Bangladesh.
Janet M PeersonDepartments of Nutrition and.
Kathryn G DeweyDepartments of Nutrition and kgdewey@ucdavis.edu.
University of California, Davis · USInternational Centre for Diarrhoeal Disease Research · BDDinajpur Medical College · BDMilton District Hospital · CANutrition Sciences (Belgium) · BEUniversity of California, Riverside · US

Funding

University of California Launching Future Leaders in Global Health Research Training ProgramD43TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIG R COHEN, Sung-Jae Lee · 2017 to 2026
$14.7M
University of California Global Health Institute Program for Fellows and ScholarsR25TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COHEN, CRAIG R, STRATHDEE, STEFFANIE A. · 2012 to 2017
$6.4M
FIC NIH HHS D43 TW009343FIC NIH HHS R25 TW009343
6 · The paper itself

Abstract

backgroundMaternal undernutrition and newborn stunting [birth length-for-age z score (LAZ) <-2] are common in Bangladesh.

objectiveThe objective was to evaluate the effect of lipid-based nutrient supplements for pregnant and lactating women (LNS-PLs) on birth outcomes.

designWe conducted a cluster-randomized effectiveness trial (the Rang-Din Nutrition Study) within a community health program in rural Bangladesh. We enrolled 4011 pregnant women at ≤20 gestational weeks; 48 clusters received iron and folic acid (IFA; 60 mg Fe + 400 μg folic acid) and 16 clusters received LNS-PLs (20 g/d, 118 kcal) containing essential fatty acids and 22 vitamins and minerals. Both of the supplements were intended for daily consumption until delivery. Primary outcomes were birth weight and length.

resultsInfants in the LNS-PL group had higher birth weights (2629 ± 408 compared with 2588 ± 413 g; P = 0.007), weight-for-age z scores (-1.48 ± 1.01 compared with -1.59 ± 1.02; P = 0.006), head-circumference-for-age z scores (HCZs; -1.26 ± 1.08 compared with -1.34 ± 1.12; P = 0.028), and body mass index z scores (-1.57 ± 1.05 compared with -1.66 ± 1.03; P = 0.005) than those in the IFA group; in adjusted models, the differences in length (47.6 ± 0.07 compared with 47.4 ± 0.04 cm; P = 0.043) and LAZ (-1.15 ± 0.04 compared with -1.24 ± 0.02; P = 0.035) were also significant. LNS-PLs reduced the risk of newborn stunting (18.7% compared with 22.6%; RR: 0.83; 95% CI: 0.71, 0.97) and small head size (HCZ <-2) (20.7% compared with 24.9%; RR: 0.85; 95% CI: 0.73, 0.98). The effects of LNS-PL on newborn stunting were greatest in infants born before a 10-wk interruption in LNS-PL distribution (n = 1301; 15.7% compared with 23.6%; adjusted RR: 0.69; 95% CI: 0.53, 0.89) and in infants born to women ≤24 y of age or with household food insecurity.

conclusionPrenatal lipid-based nutrient supplements can improve birth outcomes in Bangladeshi women, especially those at higher risk of fetal growth restriction. This trial was registered at clinicaltrials.gov as NCT01715038.

Indexed as

Birth WeightBody HeightDietary SupplementsAdolescentAdultBangladeshDietary FatsFemaleFetal DevelopmentFetal Growth RetardationGrowth DisordersHumansInfant, NewbornLactationMalnutritionMicronutrientsDietary FatsMicronutrientshead circumferenceiron and folic acidlipid-based nutrient supplementslow birth weightnewborn stunting

Identifiers

PMID26607935
PMCPMC6443293
OpenAlexW2175844398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.