ArticleEpidemiology and infection2016
Environmental factors and public health policy associated with human and rodent infection by leptospirosis: a land cover-based study in Nan province, Thailand.
Article in Epidemiology and infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Agricultural land-uses consistently exacerbate infectious disease risks in Southeast Asia.Nature communications · 2019Pooled it
- Regional and Seasonal Dynamics of Leptospirosis in Ukraine, 2023-2025.Pathogens (Basel, Switzerland) · 2026Article
- Pathogenic Leptospira species identified in dogs and cats during neutering in Thailand.PLoS neglected tropical diseases · 2026Article
- Leptospirosis in Southeast Asia: Investigating Seroprevalence, Transmission Patterns, and Diagnostic Challenges.Tropical medicine and infectious disease · 2026Review
- The Relationship Between the Spatial Occurrence ofPathogens (Basel, Switzerland) · 2024Article
- Seroprevalence of leptospirosis among blood donors in an endemic area.Scientific reports · 2023Article
- A case-control study of agricultural and behavioral factors associated with leptospirosis in Vietnam.BMC infectious diseases · 2022Article
- Spatial-temporal patterns and risk factors for human leptospirosis in Thailand, 2012-2018.Scientific reports · 2022Article
- Agro-Environmental Determinants of Leptospirosis: A Retrospective Spatiotemporal Analysis (2004-2014) in Mahasarakham Province (Thailand).Tropical medicine and infectious disease · 2021Article
- The effects of flooding and weather conditions on leptospirosis transmission in Thailand.Scientific reports · 2021Article
- Low Prevalence ofTropical medicine and infectious disease · 2020Article
- Prediction mapping of human leptospirosis using ANN, GWR, SVM and GLM approaches.BMC infectious diseases · 2019Article
- Leptospira infection in rats: A literature review of global prevalence and distribution.PLoS neglected tropical diseases · 2019Review
- Association of rodent-borne Leptospira spp. with urban environments in Malaysian Borneo.PLoS neglected tropical diseases · 2019Article
- A remotely sensed flooding indicator associated with cattle and buffalo leptospirosis cases in Thailand 2011-2013.BMC infectious diseases · 2018Article
- Association between Opisthorchis viverrini and Leptospira spp. infection in endemic Northeast Thailand.Parasitology international · 2017Article
- Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015.PLoS neglected tropical diseases · 2017Article
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptospirosis incidence has increased markedly since 1995 in Thailand, with the eastern and northern parts being the most affected regions, particularly during flooding events. Here, we attempt to overview the evolution of human prevalence during the past decade and identify the environmental factors that correlate with the incidence of leptospirosis and the clinical incidence in humans. We used an extensive survey of Leptospira infection in rodents conducted in 2008 and 2009 and the human incidence of the disease from 2003 to 2012 in 168 villages of two districts of Nan province in Northern Thailand. Using an ad-hoc developed land-use cover implemented in a geographical information system we showed that humans and rodents were not infected in the same environment/habitat in the land-use cover. High village prevalence was observed in open habitat near rivers for the whole decade, or in 2008-2009 mostly in rice fields prone to flooding, whereas infected rodents (2008-2009) were observed in patchy habitat with high forest cover, mostly situated on sloping ground areas. We also investigated the potential effects of public health campaigns conducted after the dramatic flood event of 2006. We showed that, before 2006, human incidence in villages was explained by the population size of the village according to the environmental source of infection of this disease, while as a result of the campaigns, human incidence in villages after 2006 appeared independent of their population size. This study confirms the role of the environment and particularly land use, in the transmission of bacteria, emphasized by the effects of the provincial public health campaigns on the epidemiological pattern of incidence, and questions the role of rodents as reservoirs.
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