Evidence map›Paper›PMID 26607820›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2016

Atrial fibrillation, cognitive impairment, and neuroimaging.

Jonathan Graff-Radford, Malini Madhavan, Prashanthi Vemuri, Alejandro A Rabinstein, Ruth H Cha, Michelle M Mielke, Kejal Kantarci, Val Lowe, Matthew L Senjem, Jeffrey L Gunter and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Predictive role of atrial fibrillation in cognitive decline: a systematic review and meta-analysis of 2.8 million individuals.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022
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  14. Mapping the interplay of atrial fibrillation, brain structure, and cognitive dysfunction.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  15. Blood biomarkers of Alzheimer's disease in the community: Variation by chronic diseases and inflammatory status.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  16. Review
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  19. Brain and cardiovascular-related changes are associated with aging, hypertension, and atrial fibrillation.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Jonathan Graff-RadfordDepartment of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA.
Malini MadhavanDepartment of Cardiology, Mayo Clinic and Foundation, Rochester, MN, USA.
Prashanthi VemuriDepartment of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.
Alejandro A RabinsteinDepartment of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA.
Ruth H ChaDepartment of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA.
Michelle M MielkeDepartment of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA; Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA.
Kejal KantarciDepartment of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.
Val LoweDepartment of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.
Matthew L SenjemDepartment of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.
Jeffrey L GunterDepartment of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.
David S KnopmanDepartment of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA.
Ronald C PetersenDepartment of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA.
Clifford R JackDepartment of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA.
Rosebud O RobertsDepartment of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA; Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA. Electronic address: roberts.rosebud@mayo.edu.
Mayo Clinic · USMayo Clinic in Florida · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
RECRUITMENT COREU19AG010483 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDMAN, HOWARD · 2013 to 2020
$80.6M
SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI VEMURI, PRASHANTHI · 1999 to 2018
$36.9M
PREDICTING ALZHEIMERS DISEASE WITH MAGNETIC RESONANCER01AG011378 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R. · 1993 to 2017
$12.1M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
The Frontotemporal Lobar Degeneration Neuroimaging InitiativeR01AG032306 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSEN, HOWARD J · 2009 to 2013
$10.0M
Validating the New Criteria for Preclinical Alzheimer's diseaseR01AG041851 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R., KNOPMAN, DAVID S · 2012 to 2021
$6.3M
Sex-specific Risk for Vascular Dysfunction and Cognitive DeclineP50AG044170 · NIA · MAYO CLINIC ROCHESTER · PI MILLER, VIRGINIA M · 2012 to 2017
$6.1M
Aerobic Exercise in Alzheimer's Disease: Cognition and Hippocampal Volume EffectsR01AG043392 · NIA · UNIVERSITY OF MINNESOTA · PI YU, FANG · 2013 to 2018
$3.2M
Stroke and Cognitive Impairment in Aging Chronic Kidney Disease PatientsR01AG037551 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MURRAY, ANNE M · 2011 to 2015
$2.7M
Pathological basis of MRS and DTI changes in neurodegenerative dementiaR01AG040042 · NIA · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2011 to 2015
$1.6M
NHLBI NIH HHS U01 HL096917NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG044170NIA NIH HHS R00 AG037573NIA NIH HHS R01 AG011378NIA NIH HHS R01 AG029550NIA NIH HHS R01 AG032306NIA NIH HHS R01 AG037551NIA NIH HHS R01 AG040042NIA NIH HHS R01 AG041851NIA NIH HHS R01 AG043392NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG06786NIA NIH HHS U19 AG010483
6 · The paper itself

Abstract

introductionThe objective of our study was to investigate cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer's disease and their interactions with mild cognitive impairment (MCI).

methodsMagnetic resonance imaging scans of individuals from a population-based study were analyzed for infarctions, total gray matter, and hippocampal and white matter hyperintensity volumes. A subsample underwent positron emission tomography imaging.

resultsAtrial fibrillation was associated with infarctions and lower total gray matter volume. Compared with subjects with no atrial fibrillation and no infarction, the odds ratio (95% confidence intervals) for MCI was 2.99 (1.57-5.70; P = .001) among participants with atrial fibrillation and infarction, 0.90 (0.45-1.80; P = .77) for atrial fibrillation and no infarction, and 1.50 (0.96-2.34; P = .08) for no atrial fibrillation and any infarction. DISCUSSION: Participants with both atrial fibrillation and infarction are more likely to have MCI than participants with either infarction or atrial fibrillation alone.

Indexed as

AgedAged, 80 and overApolipoproteins EAtrial FibrillationBrainCognitive DysfunctionCross-Sectional StudiesFemaleGray MatterHumansLongitudinal StudiesMagnetic Resonance ImagingMaleOrgan SizePositron-Emission TomographyWhite MatterApolipoproteins EAlzheimer's diseaseAtrial fibrillationCerebrovascular diseaseMild cognitive impairmentStroke

Identifiers

PMID26607820
PMCPMC4841716
OpenAlexW2196322924

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.