ArticleBiology of reproduction2016
The Mouse INO80 Chromatin-Remodeling Complex Is an Essential Meiotic Factor for Spermatogenesis.
Article in Biology of reproduction, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 48 citations in OpenAlex.
- Review
- H3K9me2 is a determinant for the mitosis-to-meiosis transition in female germ cells.Cell death & disease · 2026Article
- Chromatin remodeler ISW-1 orchestrates chromosome axis assembly and meiotic progression in C. elegans.Nucleic acids research · 2025Article
- Genome-Wide Association Study of Daughter Pregnancy Rate in Crossbred Dairy Cows.International journal of molecular sciences · 2025Article
- Epigenetic regulation by DNA methylation, histone modifications and chromatin remodeling complexes in controlling spermatogenesis and their dysfunction with male infertility.Cellular and molecular life sciences : CMLS · 2025Review
- SMARCA5 restricts chromatin accessibility to promote male meiosis and fertility in mammals.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Effect of Brief Maternal Exposure to Bisphenol A on the Fetal Female Germline in a Mouse Model.Environmental health perspectives · 2025Article
- INO80 regulates chromatin accessibility to facilitate suppression of sex-linked gene expression during mouse spermatogenesis.PLoS genetics · 2024Article
- The mechanism of INO80D involved in chromatin remodeling regulating spermatogenesis in Chinese mitten crab (Eriocheir sinensis).Molecular genetics and genomics : MGG · 2024Article
- Chromatin remodeler CHD8 is required for spermatogonial proliferation and early meiotic progression.Nucleic acids research · 2024Article
- Exploring Transcriptional Regulation of Beta Cell SASP by Brd4-Associated Proteins and Cell Cycle Control Protein p21.Epigenomes · 2024Article
- Efficient Enrichment of Synchronized Mouse Spermatocytes Suitable for Genome-Wide Analysis.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Envisioning a role for nuclear actin in prophase I spermatocytes.Frontiers in cell and developmental biology · 2023Review
- INO80 function is required for mouse mammary gland development, but mutation alone may be insufficient for breast cancer.Frontiers in cell and developmental biology · 2023Article
- Article
- INO80 requires a polycomb subunit to regulate the establishment of poised chromatin in murine spermatocytes.Development (Cambridge, England) · 2022Article
- Mammalian SWI/SNF chromatin remodeler is essential for reductional meiosis in males.Nature communications · 2021Article
- Chromatin remodeler INO80 mediates trophectoderm permeability barrier to modulate morula-to-blastocyst transition.Zoological research · 2021Article
- INO80 promotes H2A.Z occupancy to regulate cell fate transition in pluripotent stem cells.Nucleic acids research · 2021Article
- Epigenetic Regulation of Spermatogonial Stem Cell Homeostasis: From DNA Methylation to Histone Modification.Stem cell reviews and reports · 2021Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The ability to faithfully transmit genetic information across generations via the germ cells is a critical aspect of mammalian reproduction. The process of germ cell development requires a number of large-scale modulations of chromatin within the nucleus. One such occasion arises during meiotic recombination, when hundreds of DNA double-strand breaks are induced and subsequently repaired, enabling the transfer of genetic information between homologous chromosomes. The inability to properly repair DNA damage is known to lead to an arrest in the developing germ cells and sterility within the animal. Chromatin-remodeling activity, and in particular the BRG1 subunit of the SWI/SNF complex, has been shown to be required for successful completion of meiosis. In contrast, remodeling complexes of the ISWI and CHD families are required for postmeiotic processes. Little is known regarding the contribution of the INO80 family of chromatin-remodeling complexes, which is a particularly interesting candidate due to its well described functions during DNA double-strand break repair. Here we show that INO80 is expressed in developing spermatocytes during the early stages of meiotic prophase I. Based on this information, we used a conditional allele to delete the INO80 core ATPase subunit, thereby eliminating INO80 chromatin-remodeling activity in this lineage. The loss of INO80 resulted in an arrest during meiosis associated with a failure to repair DNA damage during meiotic recombination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.