Trial reportDiabetologia2016
The impact of gender on the long-term morbidity and mortality of patients with type 2 diabetes receiving structured personal care: a 13 year follow-up study.
Trial report in Diabetologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01074762 (The Diabetes Care in General Practice Study), which is not on this map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Diabetes Care in General Practice Study: Randomised Controlled Trial of Structured Personal Care of Type 2 Diabetes Mellitus
Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Socio-demographic determinants and effect of structured personal diabetes care: a 19-year follow-up of the randomized controlled study diabetes Care in General Practice (DCGP).BMC endocrine disorders · 2017Trial
- The Global, regional, and national burden of type 1 diabetes mellitus-related chronic kidney disease, 1990-2021: Insights from the global burden of disease study 2021 and projections to 2050.International urology and nephrology · 2026Article
- Men and type 2 diabetes: how everyday knowledge remains unshared in gendered medical encounters.International journal of qualitative studies on health and well-being · 2025Article
- Global, Regional, and National Burden of Early-Onset Alzheimer's Disease and Other Dementias in Young Adults Aged 40-64 Years, 1990-2021: A Population-Based Study.European journal of neurology · 2025Article
- African regional and national burden of diabetes mellitus and its attributable risk factors from 1990 to 2021: results from the global burden of disease study 2021.Frontiers in endocrinology · 2025Article
- Tailoring nursing interventions to empower patients: personal coping strategies and self-management in type 2 diabetes care.BMC nursing · 2024Article
- Anxiety and Depression Among Patients with Diabetes in Saudi Arabia and Egypt.Healthcare (Basel, Switzerland) · 2024Article
- Global burden of type 1 diabetes in adults aged 65 years and older, 1990-2019: population based study.BMJ (Clinical research ed.) · 2024Article
- Prevalence of depression among diabetic patients attending the Armed Forces Hospital, Southern Region, Saudi Arabia: A prospective cross-sectional study.Journal of family medicine and primary care · 2024Article
- The Description and Prediction of Incidence, Prevalence, Mortality, Disability-Adjusted Life Years Cases, and Corresponding Age-Standardized Rates for Global Diabetes.Journal of epidemiology and global health · 2023Article
- Quality of life, stress, anxiety and depression and associated factors among people with type 2 diabetes mellitus in Western region Saudi Arabia.Frontiers in psychiatry · 2023Article
- Impaired Sensitivity to Thyroid Hormones Is Associated With Elevated Blood Glucose in Coronary Heart Disease.Frontiers in endocrinology · 2022Article
- Experiences with tailoring of primary diabetes care in well-organised general practices: a mixed-methods study.BMC health services research · 2021Article
- A synergistic effect of variability in estimated glomerular filtration rate with chronic kidney disease on all-cause mortality prediction in patients with type 2 diabetes: a retrospective cohort study.Cardiovascular diabetology · 2021Observational
- Precision Health Care Elements, Definitions, and Strategies for Patients with Diabetes: A Literature Review.International journal of environmental research and public health · 2021Review
- Update on prevention of diabetic foot ulcer.Archives of medical sciences. Atherosclerotic diseases · 2021Review
- Characteristics of blood glucose distribution in a health examination population in Sichuan (2009-2017).Medicine · 2020Article
- The impact of cancer on diabetes outcomes.BMC endocrine disorders · 2019Article
- Risk factors associated with outcomes of peritoneal dialysis in Taiwan: An analysis using a competing risk model.Medicine · 2019Observational
- 17β-Estradiol Regulates Glucose Metabolism and Insulin Secretion in Rat Islet β Cells Through GPER and Akt/mTOR/GLUT2 Pathway.Frontiers in endocrinology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe aim of this study was to assess gender differences in mortality and morbidity during 13 follow-up years after 6 years of structured personal care in patients with type 2 diabetes mellitus.
methodsIn the Diabetes Care in General Practice (DCGP) multicentre, cluster-randomised, controlled trial (ClinicalTrials.gov registration no. NCT01074762), 1,381 patients newly diagnosed with type 2 diabetes were randomised to receive 6 years of either structured personal care or routine care. The intervention included regular follow-up, individualised goal setting and continuing medical education of general practitioners participating in the intervention. Patients were re-examined at the end of intervention. This observational analysis followed 970 patients for 13 years thereafter using national registries. Outcomes were all-cause mortality, incidence of diabetes-related death, any diabetes-related endpoint, myocardial infarction, stroke, peripheral vascular disease and microvascular disease.
resultsIn women, but not men, a lower HR for structured personal care vs routine care emerged for any diabetes-related endpoint (0.65, p = 0.004, adjusted; 73.4 vs 107.7 events per 1,000 patient-years), diabetes-related death (0.70, p = 0.031; 34.6 vs 45.7), all-cause mortality (0.74, p = 0.028; 55.5 vs 68.5) and stroke (0.59, p = 0.038; 15.6 vs 28.9). This effect was different between men and women for diabetes-related death (interaction p = 0.015) and all-cause mortality (interaction p = 0.005). CONCLUSIONS/
interpretationCompared with routine care, structured personal diabetes care reduced all-cause mortality and diabetes-related death in women but not in men. This gender difference was also observed for any diabetes-related outcome and stroke but was not statistically significant after extensive multivariate adjustment. These observational results from a post hoc analysis of a randomised controlled trial cannot be explained by intermediate outcomes like HbA1c alone, but involves complex social and cultural issues of gender. There is a need to rethink treatment schemes for both men and women to gain benefit from intensified treatment efforts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.