ArticleDiabetologia2016
Age at menarche and the risk of diabetic microvascular complications in patients with type 1 diabetes.
Article in Diabetologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- ISPAD Clinical Practice Consensus Guidelines 2018: Other complications and associated conditions in children and adolescents with type 1 diabetes.Pediatric diabetes · 2018Guideline
- Age at Menarche and Its Association with Cardiovascular Disease in Women with Childhood-Onset Type 1 Diabetes (T1D).Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Gonadal dysfunction in women with diabetes mellitus.Endocrine · 2024Review
- Delayed menarche in children and adolescents with type 1 diabetes mellitus: a systematic review and meta-analysis.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2024Review
- Sex-Related Aspects in Diabetic Kidney Disease-An Update.Journal of clinical medicine · 2023Review
- The Influence of Different Types of Diabetes on Vascular Complications.Journal of diabetes research · 2022Review
- Early Onset Age Increased the Risk of Diabetic Retinopathy in Type 2 Diabetes Patients with Duration of 10-20 Years and HbA1C ≥7%: A Hospital-Based Case-Control Study.International journal of endocrinology · 2021Article
- An evidence map of clinical practice guideline recommendations and quality on diabetic retinopathy.Eye (London, England) · 2020Article
- Evaluation ofInternational journal of fertility & sterility · 2020Article
- Effect of age at menarche on microvascular complications among women with Type 1 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2019Article
- Reproductive disturbances among Saudi adolescent girls and young women with type 1 diabetes mellitus.World journal of diabetes · 2017Article
- Early changes in cardiovascular structure and function in adolescents with type 1 diabetes.Cardiovascular diabetology · 2016Observational
- Severity of diabetic retinopathy at the first ophthalmological examination in the Lebanese population.Therapeutic advances in ophthalmologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe aim of this study was to evaluate the relationship among age at onset of diabetes, age at onset of menarche and risk of diabetic nephropathy and laser-treated retinopathy in type 1 diabetes.
methodsData related to age at menarche were collected through questionnaires and were available for 1,304 women who participated in the Finnish Diabetic Nephropathy Study (FinnDiane). A possible association between age at menarche and diabetic nephropathy and retinopathy was investigated.
resultsThere was an inverse relationship between the age at onset of diabetes and age at menarche: the younger the age at onset of diabetes, the higher the age at menarche (p < 0.0001). A non-linear relationship between the age of menarche and risk of diabetic microvascular complications was found in patients with diabetes onset before menarche, but there was no such association in patients with diabetes onset after menarche. Women with delayed menarche (> mean age + 2 years) had a 2.30 (95% CI 1.27, 4.17; p < 0.006) times higher risk of nephropathy compared with the women who underwent menarche at the mean age ± 2 years. Delayed menarche also increased the risk of retinopathy (OR 2.34 [95% CI 1.36, 4.01]). After excluding patients with nephropathy, the OR for retinopathy was 2.11 (95% CI 1.15, 3.90). Earlier menarche (< mean age - 2 years) did not have any effect on this risk. CONCLUSIONS/
interpretationDelayed menarche was associated with an increased risk of diabetic nephropathy and retinopathy, whereas early menarche was not. Delayed menarche may be used as a new tool to identify women at risk of diabetic microvascular complications.
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