ReviewThe Journal of physiology2016
Spontaneous activity in the microvasculature of visceral organs: role of pericytes and voltage-dependent Ca(2+) channels.
Review in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Regulation of Autonomic Motility in Human Gastric Muscle and the Gastroepiploic Artery by Stretch and pH.Journal of muscle research and cell motility · 2025Article
- A multiscale vascular atlas of blood vessels supplying the urinary bladder of male and female mice.American journal of physiology. Renal physiology · 2025Article
- MgSOTheranostics · 2025Article
- A Method to Isolate Pericytes From the Mouse Urinary Bladder for the Study of Diabetic Bladder Dysfunction.International neurourology journal · 2020Article
- Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia.Frontiers in aging neuroscience · 2020 · on this mapReview
- Synchrony of spontaneous CaJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2020Review
- Introduction to ion channels and calcium signaling in the microcirculation.Current topics in membranes · 2020Review
- Excitability and contractility in arterioles and venules from the urinary bladder.Current topics in membranes · 2020Review
- Role of KPflugers Archiv : European journal of physiology · 2019Article
- Calcium Receptor and Nitric Oxide Synthase Expression in Circular Muscle of Lower Esophagus from Patients with Achalasia.Chinese medical journal · 2018Article
- Role of capillary pericytes in the integration of spontaneous CaThe Journal of physiology · 2018Article
- Setting the pace for labour.The Journal of physiology · 2018Article
- Contractile properties of periosteal arterioles in the guinea-pig tibia.Pflugers Archiv : European journal of physiology · 2017Article
- Properties of synchronous spontaneous CaPflugers Archiv : European journal of physiology · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microvasculature plays a primary role in the interchange of substances between tissues and the circulation. In visceral organs that undergo considerable distension upon filling, the microvasculature appears to display intrinsic contractile properties to maintain their flow. Submucosal venules in the bladder or gastrointestinal tract generate rhythmic spontaneous phasic constrictions and associated Ca(2+) transients. These events are initiated within either venular pericytes or smooth muscle cells (SMCs) arising from spontaneous Ca(2+) release from the sarcoplasmic reticulum (SR) and the opening of Ca(2+) -activated chloride channels (CaCCs) that trigger Ca(2+) influx through L-type voltage-dependent Ca(2+) channels (VDCCs). L-type VDCCs also play a critical role in maintaining synchrony within the contractile mural cells. In the stomach myenteric layer, spontaneous Ca(2+) transients originating in capillary pericytes appear to spread to their neighbouring arteriolar SMCs. Capillary Ca(2+) transients primarily rely on SR Ca(2+) release, but also require Ca(2+) influx through T-type VDCCs for their synchrony. The opening of T-type VDCCs also contribute to the propagation of Ca(2+) transients into SMCs. In visceral microvasculature, pericytes act as either spontaneously active contractile machinery of the venules or as pacemaker cells generating synchronous Ca(2+) transients that drive spontaneous contractions in upstream arterioles. Thus pericytes play different roles in different vascular beds in a manner that may well depend on the selective expression of T-type and L-type Ca(2+) channels.
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