Evidence map›Paper›PMID 26607483›Full record

ArticleBrain stimulation

Asynchronous Distributed Multielectrode Microstimulation Reduces Seizures in the Dorsal Tetanus Toxin Model of Temporal Lobe Epilepsy.

Sharanya Arcot Desai, John D Rolston, Courtney E McCracken, Steve M Potter, Robert E Gross

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

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  13. The role of the basal ganglia in the control of seizure.Journal of neural transmission (Vienna, Austria : 1996) · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sharanya Arcot DesaiThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, USA; Laboratory for Neuroengineering, Georgia Institute of Technology, Atlanta, USA.
John D RolstonDepartment of Neurological Surgery, University of California, San Francisco, USA.
Courtney E McCrackenDepartment of Pediatrics, Emory University School of Medicine, Atlanta, USA.
Steve M PotterThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, USA; Laboratory for Neuroengineering, Georgia Institute of Technology, Atlanta, USA.
Robert E GrossThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, USA; Department of Neurosurgery, Emory University School of Medicine, Atlanta, USA. Electronic address: rgross@emory.edu.
Emory University · USGeorgia Institute of Technology · USNeurological Surgery · US

Funding

Distributed microstimulation for epilepsyR21NS054809 · NINDS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 2008 to 2009
$372k
NINDS NIH HHS NS05480NINDS NIH HHS R21 NS054809
6 · The paper itself

Abstract

backgroundElectrical brain stimulation has shown promise for reducing seizures in drug-resistant epilepsy, but the electrical stimulation parameter space remains largely unexplored. New stimulation parameters, electrode types, and stimulation targets may be more effective in controlling seizures compared to currently available options. HYPOTHESIS: We hypothesized that a novel electrical stimulation approach involving distributed multielectrode microstimulation at the epileptic focus would reduce seizure frequency in the tetanus toxin model of temporal lobe epilepsy.

methodsWe explored a distributed multielectrode microstimulation (DMM) approach in which electrical stimulation was delivered through 15 33-µm-diameter electrodes implanted at the epileptic focus (dorsal hippocampus) in the rat tetanus toxin model of temporal lobe epilepsy.

resultsWe show that hippocampal theta (6-12 Hz brain oscillations) is decreased in this animal model during awake behaving conditions compared to control animals (p < 10(-4)). DMM with biphasic, theta-range (6-12 Hz/electrode) pulses delivered asynchronously on the 15 microelectrodes was effective in reducing seizures by 46% (p < 0.05). When theta pulses or sinusoidal stimulation was delivered synchronously and continuously on the 15 microelectrodes, or through a single macroelectrode, no effects on seizure frequency were observed. High frequency stimulation (>16.66 Hz/per electrode), in contrast, had a tendency to increase seizure frequency.

conclusionsThese results indicate that DMM could be a new effective approach to therapeutic brain stimulation for reducing seizures in epilepsy.

Indexed as

Deep Brain StimulationAnimalsEpilepsy, Temporal LobeHippocampusMaleRatsRats, Sprague-DawleySeizuresTetanus ToxinTheta RhythmTetanus ToxinEpilepsyMicrostimulationMultielectrode arrayMulti-site stimulationTheta oscillations

Identifiers

PMID26607483
PMCPMC4724241
OpenAlexW1180932611

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.