ArticleProceedings of the National Academy of Sciences of the United States of America2015
Temporal fate mapping reveals age-linked heterogeneity in naive T lymphocytes in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 57 citations in OpenAlex.
- Quorum sensing underlies the establishment and maintenance of marginal zone B cells.bioRxiv : the preprint server for biology · 2026Article
- Diversity, Equality, and Inclusion in the naïve T Cell Receptor Repertoire.Immunological reviews · 2026Review
- Tissue-resident memory CD4eLife · 2025Article
- A linear ontogeny accounts for the development of naive, memory, and tumor-infiltrating regulatory T cells in mice.Science immunology · 2025Article
- Evidence for a RIPK1-independent survival mechanism for CASPASE-8 in αβ T cells.Discovery immunology · 2025Article
- Transient PU.1 low fetal progenitors generate lymphoid progeny that contribute to adult immunity.Life science alliance · 2024Article
- The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host.PLoS biology · 2024Article
- Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases.Cell death & disease · 2024Review
- The dynamics and longevity of circulating CD4bioRxiv : the preprint server for biology · 2024Article
- Proteostasis in T cell aging.Seminars in immunology · 2023Review
- Modeling T Cell Fate.Annual review of immunology · 2023Review
- Age-associated remodeling of T cell immunity and metabolism.Cell metabolism · 2023Review
- Quantifying cellular dynamics in mice using a novel fluorescent division reporter system.Frontiers in immunology · 2023Article
- Why are cell populations maintained via multiple compartments?Journal of the Royal Society, Interface · 2022Article
- Article
- Fate-mapping mice: new tools and technology for immune discovery.Trends in immunology · 2022Review
- Selection influences naive CD8+ TCR-β repertoire sharing.Immunology · 2021Article
- How Naive T-Cell Clone Counts Are Shaped By Heterogeneous Thymic Output and Homeostatic Proliferation.Frontiers in immunology · 2021Article
- Fate Mapping Quantifies the Dynamics of B Cell Development and Activation throughout Life.Cell reports · 2020Article
- The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes.eLife · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Understanding how our T-cell compartments are maintained requires knowledge of their population dynamics, which are typically quantified over days to weeks using the administration of labels incorporated into the DNA of dividing cells. These studies present snapshots of homeostatic dynamics and have suggested that lymphocyte populations are heterogeneous with respect to rates of division and/or death, although resolving the details of such heterogeneity is problematic. Here we present a method of studying the population dynamics of T cells in mice over timescales of months to years that reveals heterogeneity in rates of division and death with respect to the age of the host at the time of thymic export. We use the transplant conditioning drug busulfan to ablate hematopoetic stem cells in young mice but leave the peripheral lymphocyte compartments intact. Following their reconstitution with congenically labeled (donor) bone marrow, we followed the dilution of peripheral host T cells by donor-derived lymphocytes for a year after treatment. Describing these kinetics with mathematical models, we estimate rates of thymic production, division and death of naive CD4 and CD8 T cells. Population-averaged estimates of mean lifetimes are consistent with earlier studies, but we find the strongest support for a model in which both naive T-cell pools contain kinetically distinct subpopulations of older host-derived cells with self-renewing capacity that are resistant to displacement by naive donor lymphocytes. We speculate that these incumbent cells are conditioned or selected for increased fitness through homeostatic expansion into the lymphopenic neonatal environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.