Evidence map›Paper›PMID 26607420›Full record

ArticleDiagnostic microbiology and infectious disease2016

Epidemiology and antimicrobial susceptibilities of wound isolates of obligate anaerobes from combat casualties.

Brian K White, Katrin Mende, Amy C Weintrob, Miriam L Beckius, Wendy C Zera, Dan Lu, William Bradley, David R Tribble, Elizabeth R Schnaubelt, Clinton K Murray and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2020
    Article
  3. Article
  4. Antibiotic efficacy in the complex infection environment.Current opinion in microbiology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Brian K WhiteSan Antonio Military Medical Center, Joint Base San Antonio, Fort Sam Houston, TX, USA. Electronic address: Brian.K.White100.mil@mail.mil.
Katrin MendeSan Antonio Military Medical Center, Joint Base San Antonio, Fort Sam Houston, TX, USA; Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD USA.
Amy C WeintrobInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD USA; Walter Reed National Military Medical Center, Bethesda, MD, USA.
Miriam L BeckiusSan Antonio Military Medical Center, Joint Base San Antonio, Fort Sam Houston, TX, USA.
Wendy C ZeraSan Antonio Military Medical Center, Joint Base San Antonio, Fort Sam Houston, TX, USA; Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD USA.
Dan LuInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD USA.
William BradleySan Antonio Military Medical Center, Joint Base San Antonio, Fort Sam Houston, TX, USA; Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD USA.
David R TribbleInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Elizabeth R SchnaubeltLandstuhl Regional Medical Center, Germany.
Clinton K MurraySan Antonio Military Medical Center, Joint Base San Antonio, Fort Sam Houston, TX, USA.
Infectious Disease Clinical Research Program Trauma Infectious Disease Outcome Study Group

Funding

DATA CENTER FOR EPIDEMIOLOGIC INVESTIGATIONS OF HIVN01AI005072 · NIAID · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MCKINLAY, SONJA M · 1990 to 1994
–
NIAID NIH HHS Y01 AI005072
6 · The paper itself

Abstract

Data from recent conflicts related to war wounds and obligate anaerobes are limited. We define the epidemiology and antimicrobial susceptibility of obligate anaerobes from Iraq and Afghanistan casualties (6/2009-12/2013), as well as their association with clinical outcomes. Susceptibility against eleven antibiotics (7 classes) was tested. Overall, 59 patients had 119 obligate anaerobes identified (83 were first isolates). Obligate anaerobes were isolated 7-13 days post-injury, primarily from lower extremity wounds (43%), and were largely Bacteroides spp. (42%) and Clostridium spp. (19%). Patients with pelvic wounds were more likely to have Bacteroides spp. and concomitant resistant gram-negative aerobes. Seventy-three percent of isolates were resistant to ≥1 antimicrobials. Bacteroides spp. demonstrated the most resistance (16% of first isolates). Patients with resistant isolates had similar outcomes to those with susceptible strains. Serial recovery of isolates occurred in 15% of patients and was significantly associated with isolation of Bacteroides spp., along with resistant gram-negative aerobes.

Indexed as

AdultAfghanistanAnti-Bacterial AgentsBacteria, AnaerobicBacterial InfectionsDrug Resistance, BacterialHumansIraqMaleMicrobial Sensitivity TestsTreatment OutcomeWarfareWound InfectionWounds and InjuriesYoung AdultAnti-Bacterial AgentsAnaerobesAntimicrobial susceptibilityTrauma-related infectionsWar wounds

Identifiers

PMID26607420
PMCPMC4716868

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.