Evidence map›Paper›PMID 26607255›Full record

ReviewBrain research2016

Evidence for a specialized role of the locus coeruleus noradrenergic system in cortical circuitries and behavioral operations.

Daniel J Chandler

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Pooled it
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  7. Review
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  13. Frequency Specific Optogenetic Stimulation of the Locus Coeruleus Induces Task-Relevant Plasticity in the Motor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  14. Article
  15. Article
  16. Local extracellular KProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Daniel J ChandlerDepartment of Neurobiology and Anatomy Drexel University College of Medicine, Philadelphia, PA 19129, USA. Electronic address: Daniel.chandler@drexelmed.edu.
Drexel University · US

Funding

Locus Coeruleus Function and Methylphenidate ActionR01DA017960 · NIDA · DREXEL UNIVERSITY · PI WATERHOUSE, BARRY DALE · 2004 to 2013
$3.1M
Heterogeneous properties of LC efferents to modality-specific terminal fieldsR01MH101178 · NIMH · ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED · PI WATERHOUSE, BARRY DALE · 2014 to 2018
$1.9M
Cortical Norepinephrine and Adolescent Executive FunctionR21MH087921 · NIMH · UNIVERSITY OF NEW HAMPSHIRE · PI MCGAUGHY, JILL ANN · 2010 to 2011
$397k
NIDA NIH HHS R01 DA017960NIMH NIH HHS R01 MH101178NIMH NIH HHS R21 MH087921
6 · The paper itself

Abstract

The brainstem nucleus locus coeruleus (LC) innervates the entire central nervous system and is the primary source of norepinephrine (NE) to the neocortex. While classically considered a homogenous modulator of forebrain activity by virtue of highly widespread and divergent axons, recent behavioral and pharmacological evidence suggest this nucleus may execute distinct operations within functionally distinct terminal fields. Summarized in this review are the anatomical and physiological properties of the nucleus within a historical context that led to the interpretation of the nucleus as a homogeneous entity with uniform and simultaneous actions throughout its terminal fields. Also included are findings from several laboratories which point to a more nuanced model of LC/NE function that parallels that seen in other forebrain-projecting monoaminergic nuclei. Such compartmentalized models of the nucleus promote the idea that specific LC circuits are involved in discrete behavioral operations, and therefore, by identifying the networks that are engaged by LC, the substrates for these behaviors can be identified and manipulated. Perturbations in the functional anatomy and physiology of this system may be related to neuropsychiatric conditions associated with dysregulation of the LC-noradrenergic system such as attention deficit hyperactivity disorder. Recent findings regarding the organization and operation of the LC/NE system collectively challenge the classical view of the nucleus as a relatively homogenous modulator of forebrain activity and provide the basis for a renewed scientific interest in this region of the brain. This article is part of a Special Issue entitled SI: Noradrenergic System.

Indexed as

AnimalsBehaviorCerebral CortexHumansLocus CoeruleusNeural PathwaysNeuronsNorepinephrineNorepinephrineBehaviorLocus coeruleusMotor cortexNorepinephrinesPrefrontal cortex

Identifiers

PMID26607255
PMCPMC4879003
OpenAlexW2180270433

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.