ArticleDysphagia2016
A Comparative Study Between Modified Starch and Xanthan Gum Thickeners in Post-Stroke Oropharyngeal Dysphagia.
Article in Dysphagia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 5 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- A Systematic Review and Meta-Analysis on the Application of Thickened Liquids to Treat Adults With Neurogenic Dysphagia.Journal of oral rehabilitation · 2025Pooled it
- Pooled it
- Pooled it
- Modifying the consistency of food and fluids for swallowing difficulties in dementia.The Cochrane database of systematic reviews · 2018Pooled it
- The influence of food texture and liquid consistency modification on swallowing physiology and function: a systematic review.Dysphagia · 2015Pooled it
- Effect of a gum-based thickener on the safety of swallowing in patients with poststroke oropharyngeal dysphagia.Neurogastroenterology and motility · 2019Trial
- Article
- Different Alginate Spherification Methods for Producing Hydrogel Beads Loaded with Vitamins B9 and B12 to Support Hydration in Older Adults with Dysphagia.Gels (Basel, Switzerland) · 2026Article
- Hydrocolloid Effects on Shear and Extensional Rheology.Dysphagia · 2026Article
- The Impact of Rheological Characteristics on the Swallowing Dynamics of Xanthan Gum-Based Thickeners.Foods (Basel, Switzerland) · 2026Article
- Salivary ⍺-Amylase Time-Effect on the Main Groups of Thickening Products Intended to Manage Patients with Oropharyngeal Dysphagia.Foods (Basel, Switzerland) · 2025Article
- Early application value of flexible laryngoscope swallowing function assessment in patients after partial laryngectomy.Scientific reports · 2025Article
- Article
- Medication Lubricants for Oral Delivery of Drugs: Oral Processing Reduces Thickness, Changes Characteristics, and Improves Dissolution Profile.Pharmaceutics · 2024Article
- Exploring the interaction of viscosity and nipple design on feeding performance in an infant pig model.Journal of texture studies · 2023Article
- Article
- Effects of Food and Liquid Properties on Swallowing Physiology and Function in Adults.Dysphagia · 2023Review
- Rheological Issues on Oropharyngeal Dysphagia.Dysphagia · 2023Review
- Research hotspots and trends in post-stroke dysphagia: a bibliometric analysis.Frontiers in neuroscience · 2023Article
- Proposal for a Standard Protocol to Assess the Rheological Behavior of Thickening Products for Oropharyngeal Dysphagia.Nutrients · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thickeners are used in post-stroke oropharyngeal dysphagia (OD) as a compensatory therapeutic strategy against aspirations. To compare the therapeutic effects of modified starch (MS) and xanthan gum (XG) thickeners on swallow safety and efficacy in chronic post-stroke OD patients using clinical and videofluoroscopic (VFS) assessment. Patients were studied by clinical assessment (volume-viscosity swallow test, V-VST) and VFS using 3 volumes (5, 10, 20 mL) and 3 viscosities (liquid, nectar and spoon thick), comparing MS and XG. We studied 122 patients (46MS, 76XG). (A) V-VST showed that both thickeners similarly improved safety of swallow. Prevalence of safe swallowing significantly increased with enhanced viscosity (P < 0.001 vs liquid), MS: 47.83 % at liquid, 84.93 % at nectar and 92.96 % at spoon thick; XG: 55.31 % at liquid, 77.78 % at nectar and 97.84 % at spoon thick. Patients on MS reported higher prevalence of pharyngeal residue at spoon-thick viscosities. (B) VFS: increasing bolus viscosity with either thickener increased prevalence of safe swallows (P < 0.001 vs liquid), MS: 30.25 % liquid, 61.07 % nectar and 92.64 % spoon thick; XG: 29.12 % liquid, 71.30 % nectar and 89.91 % spoon thick. Penetration-aspiration scale score was significantly reduced with increased viscosity with both thickeners. MS increased oral and pharyngeal residues at nectar and spoon-thick viscosities but XG did not. Timing of airway protection mechanisms and bolus velocity were not affected by either thickener. Increasing bolus viscosity with MS and XG thickeners strongly and similarly improved safety of swallow in chronic post-stroke OD by a compensatory mechanism; in contrast only MS thickeners increased oropharyngeal residue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.