Evidence map›Paper›PMID 26607130›Full record

ReviewThe Lancet. Infectious diseases2015

Extensively drug-resistant tuberculosis in a young child after travel to India.

Nicole Salazar-Austin, Alvaro A Ordonez, Alice Jenh Hsu, Jane E Benson, Mahadevappa Mahesh, Elizabeth Menachery, Jafar H Razeq, Max Salfinger, Jeffrey R Starke, Aaron M Milstone and 3 more

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Lancet. Infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Nuclear Medicine Imaging Tools in Fever of Unknown Origin: Time for a Revisit and Appropriate Use Criteria.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  3. Article
  4. Review
  5. Review
  6. Chest Imaging for Pulmonary TB-An Update.Pathogens (Basel, Switzerland) · 2022
    Review
  7. Animal Models of COVID-19: Nonhuman Primates.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  8. Article
  9. Review
  10. Travel-Related Antimicrobial Resistance: A Systematic Review.Tropical medicine and infectious disease · 2021
    Review
  11. Review
  12. Review
  13. Radiosynthesis and Biodistribution ofACS infectious diseases · 2020
    Article
  14. Review
  15. Article
  16. Review
  17. Balancing the Risks of Radiation and Anesthesia in Pediatric Patients.Journal of the American College of Radiology : JACR · 2017
    Article
  18. Article
  19. Review
  20. Novel interferon-gamma assays for diagnosing tuberculosis in young children in India.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Nicole Salazar-AustinDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alvaro A OrdonezDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alice Jenh HsuDepartment of Pharmacy, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jane E BensonRussell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mahadevappa MaheshRussell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Elizabeth MenacheryHoward County Health Department, Columbia, MD, USA.
Jafar H RazeqMaryland Department of Health and Mental Hygiene, Laboratories Administration, Baltimore, MD, USA.
Max SalfingerNational Jewish Health Mycobacteriology Laboratory, Denver, CO, USA.
Jeffrey R StarkeDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Aaron M MilstoneDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Hospital Epidemiology and Infection Control, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nicole ParrishDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Eric L NuermbergerCenter for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sanjay K JainDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: sjain5@jhmi.edu.
Johns Hopkins University · USJohns Hopkins Medicine · USBaylor College of Medicine · USHoward County Health Department · USMaryland Department of Health · USUniversity of Colorado Denver · US

Funding

Research Training in Pediatric Infectious DiseasesT32AI052071 · NIAID · JOHNS HOPKINS UNIVERSITY · PI AARON M MILSTONE · 2002 to 2026
$5.2M
Novel Imaging Tracers for Rapid and Noninvasive Assessment of Bacterial InfectionR01EB020539 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2014 to 2018
$3.6M
Novel imaging biomarkers to address fundamental controversies in TB pathogenesisDP2OD006492 · OD · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2009 to 2014
$2.9M
Molecular Imaging for Pulmonary Infections and InflammationR01HL131829 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2016 to 2018
$2.2M
Molecular Imaging for Macrophage-Associated Pulmonary InflammationR01HL116316 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2012 to 2014
$1.2M
NHLBI NIH HHS R01 HL116316NHLBI NIH HHS R01-HL116316NHLBI NIH HHS R01 HL131829NIAID NIH HHS T32 AI052071NIAID NIH HHS T32-AI052071NIBIB NIH HHS R01 EB020539NIBIB NIH HHS R01-EB020539NIH HHS DP2 OD006492NIH HHS DP2-OD006492
6 · The paper itself

Abstract

Extensively drug-resistant (XDR) tuberculosis is becoming increasingly prevalent worldwide, but little is known about XDR tuberculosis in young children. In this Grand Round we describe a 2-year-old child from the USA who developed pneumonia after a 3 month visit to India. Symptoms resolved with empirical first-line tuberculosis treatment; however, a XDR strain of Mycobacterium tuberculosis grew in culture. In the absence of clinical or microbiological markers, low-radiation exposure pulmonary CT imaging was used to monitor treatment response, and guide an individualised drug regimen. Management was complicated by delays in diagnosis, uncertainties about drug selection, and a scarcity of child-friendly formulations. Treatment has been successful so far, and the child is in remission. This report of XDR tuberculosis in a young child in the USA highlights the risks of acquiring drug-resistant tuberculosis overseas, and the unique challenges in management of tuberculosis in this susceptible population.

Indexed as

Antitubercular AgentsChild, PreschoolExtensively Drug-Resistant TuberculosisFemaleHumansIndiaMycobacterium tuberculosisPneumonia, BacterialRadiographyTravelTuberculosis, PulmonaryUnited StatesAntitubercular Agents

Identifiers

PMID26607130
PMCPMC4843989
OpenAlexW2173313663

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.