ArticleNeuron2015
Lamination Speeds the Functional Development of Visual Circuits.
Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Conservation of retinal direction-selective circuits across vertebrate species.Current opinion in genetics & development · 2026Review
- Canalization of neural dynamics by δ-protocadherins in the developing zebrafish optic tectum.PLoS genetics · 2026Article
- Lrrn-mediated retinal ganglion cell targeting drives visual circuit assembly for brightness and contrast detection.Science advances · 2026Article
- Afadin-deficient mouse retinas exhibit severe neuronal lamination defects but preserve visual functions.eLife · 2025Article
- Artificial embodied circuits uncover neural architectures of vertebrate visuomotor behaviors.Science robotics · 2025Article
- Article
- From perception to behavior: The neural circuits underlying prey hunting in larval zebrafish.Frontiers in neural circuits · 2023Review
- Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling.Nature neuroscience · 2022Article
- Wiring subcortical image-forming centers: Topography, laminar targeting, and map alignment.Current topics in developmental biology · 2021Review
- Article
- Functional Integration of Newborn Neurons in the Zebrafish Optic Tectum.Frontiers in cell and developmental biology · 2019Review
- Optimization of interneuron function by direct coupling of cell migration and axonal targeting.Nature neuroscience · 2018Article
- Fate and freedom in developing neocortical circuits.Nature communications · 2017Review
- The laminar organization of theeLife · 2017Article
- Functional Interactions between Newborn and Mature Neurons Leading to Integration into Established Neuronal Circuits.Current biology : CB · 2017Article
- Uncoupling of neurogenesis and differentiation during retinal development.The EMBO journal · 2017Article
- Wiring visual systems: common and divergent mechanisms and principles.Current opinion in neurobiology · 2017Review
- A Three-Layer Network Model of Direction Selective Circuits in the Optic Tectum.Frontiers in neural circuits · 2017Article
- Reconnecting Eye to Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- A crystal-clear zebrafish for in vivo imaging.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
A common feature of the brain is the arrangement of synapses in layers. To examine the significance of this organizational feature, we studied the functional development of direction-selective (DS) circuits in the tectum of astray mutant zebrafish in which lamination of retinal ganglion cell (RGC) axons is lost. We show that although never laminar, the tuning of DS-RGC axons targeting the mutant tectum is normal. Analysis of mutant tectal neurons at late developmental stages reveals that directional tuning is indistinguishable from wild-type larvae. Furthermore, we show that structural plasticity of tectal dendrites and RGC axons compensates for the loss of lamination, establishing connectivity between DS-RGCs and their normal tectal targets. However, tectal direction selectivity is severely perturbed at earlier developmental stages. Thus, the formation of synaptic laminae is ultimately dispensable for the correct wiring of direction-selective tectal circuits, but it is crucial for the rapid assembly of these networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.