ArticleNeuron2015
Molecularly Defined Circuitry Reveals Input-Output Segregation in Deep Layers of the Medial Entorhinal Cortex.
Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 63 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 135 citations in OpenAlex.
- Instructive signals drive learning through behavioral timescale synaptic plasticity in the hippocampus and beyond.Current research in neurobiology · 2026Article
- An Update on the Model of Connectivity of the Hippocampal Formation (I): The Perforant Pathway to the Dentate Gyrus.Hippocampus · 2026Article
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- Biased synaptic activation of dentate granule cells by exercise reflects inputs from the lateral entorhinal cortex.bioRxiv : the preprint server for biology · 2026Article
- Slow synaptic plasticity from the hippocampus underlies gradual mapping and fragmentation of novel spaces by grid cells.bioRxiv : the preprint server for biology · 2025Article
- Environmental Novelty Modulates Rapid Cortical Plasticity During Navigation.bioRxiv : the preprint server for biology · 2025Article
- Spatial coding dysfunction and network instability in the aging medial entorhinal cortex.Nature communications · 2025Article
- A galanin-positive population of lumbar spinal cord neurons modulates sexual arousal and copulatory behavior in male mice.Nature communications · 2025Article
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- Hippocampus shapes entorhinal cortical output through a direct feedback circuit.Nature neuroscience · 2025Article
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- Stimulation of an entorhinal-hippocampal extinction circuit facilitates fear extinction in a post-traumatic stress disorder model.The Journal of clinical investigation · 2024Article
- Projection neurons from medial entorhinal cortex to basolateral amygdala are critical for the retrieval of morphine withdrawal memory.iScience · 2024Article
- Modeling the grid cell activity based on cognitive space transformation.Cognitive neurodynamics · 2024Article
- A non-canonical visual cortical-entorhinal pathway contributes to spatial navigation.Nature communications · 2024Article
- Outer layer of Vb neurons in medial entorhinal cortex project to hippocampal dentate gyrus in mice.Molecular brain · 2024Article
- Distribution Patterns of Subgroups of Inhibitory Neurons Divided by Calbindin 1.Molecular neurobiology · 2023Article
- Theta-band phase locking during encoding leads to coordinated entorhinal-hippocampal replay.Current biology : CB · 2023Article
- Dissecting cell-type-specific pathways in medial entorhinal cortical-hippocampal network for episodic memory.Journal of neurochemistry · 2023Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Deep layers of the medial entorhinal cortex are considered to relay signals from the hippocampus to other brain structures, but pathways for routing of signals to and from the deep layers are not well established. Delineating these pathways is important for a circuit level understanding of spatial cognition and memory. We find that neurons in layers 5a and 5b have distinct molecular identities, defined by the transcription factors Etv1 and Ctip2, and divergent targets, with extensive intratelencephalic projections originating in layer 5a, but not 5b. This segregation of outputs is mirrored by the organization of glutamatergic input from stellate cells in layer 2 and from the hippocampus, with both preferentially targeting layer 5b over 5a. Our results suggest a molecular and anatomical organization of input-output computations in deep layers of the MEC, reveal precise translaminar microcircuitry, and identify molecularly defined pathways for spatial signals to influence computation in deep layers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.