ArticleHypertension research : official journal of the Japanese Society of Hypertension2016
Masked hypertension and its associated cardiovascular risk in young individuals: the African-PREDICT study.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Observational study and participant-level meta-analysis on antihypertensive drug treatment-related cardiovascular risk.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Pooled it
- A pilot study on the relationship between thermal habits, chronic inflammation, and arterial stiffness in young adults.BMC research notes · 2025Article
- Machine learning model for detecting masked hypertension in young adults.Frontiers in physiology · 2025Article
- Identifying a metabolomics profile associated with masked hypertension in two independent cohorts: Data from the African-PREDICT and SABPA studies.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Linkage to HIV care and hypertension and diabetes control in rural South Africa: Results from the population-based Vukuzazi Study.PLOS global public health · 2022 · on this mapArticle
- Contribution of single office aortic systolic blood pressure measurements to the detection of masked hypertension: data from two separate cohorts.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Inflammation and hypertension development: A longitudinal analysis of the African-PREDICT study.International Journal of Cardiology. Hypertension · 2020Article
- The African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT): Design, recruitment and initial examination.European journal of preventive cardiology · 2019Observational
- Assessing tobacco use in an African population: Serum and urine cotinine cut-offs from South Africa.Drug and alcohol dependence · 2019Article
- Healthy aging and carotid performance: strain measures and β-stiffness index.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Prevalence of white coat and masked hypertension in Africa: A systematic review and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2018Review
- Microcirculation and biomarkers in patients with resistant or mild-to-moderate hypertension: a cross-sectional study.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Monitoring the South African population's salt intake: spot urine v. 24 h urine.Public health nutrition · 2018Article
- Who removes the mask of hypertension?Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Higher Frequency of Nocturnal Blood Pressure Dipping but Not Heart Rate Dipping in Inflammatory Bowel Disease.Digestive diseases and sciences · 2017Article
- Recent advances in understanding hypertension development in sub-Saharan Africa.Journal of human hypertension · 2017Review
- The ratio of monocyte frequency to HDL cholesterol level as a predictor of asymptomatic organ damage in patients with primary hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Monocyte Chemoattractant Protein-1 and Large Artery Structure and Function in Young Individuals: The African-PREDICT Study.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
- Predictors of Hypertension in a Population of Undergraduate Students in Sierra Leone.International journal of hypertension · 2017Article
- Clinical and Epidemiological Implications of 24-Hour Ambulatory Blood Pressure Monitoring for the Diagnosis of Hypertension in Kenyan Adults: A Population-Based Study.Journal of the American Heart Association · 2016Article
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10 authors.
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Abstract
Hypertension prevalence is increasing globally, yet little is known about the occurrence of masked hypertension (MHT) in young, sub-Saharan African adults, and how it relates to elevated cardiovascular risk. The African-PREDICT study (recruitment based on normotensive clinic blood pressure (BP)) determined the frequency of MHT and its relationship with arterial stiffness and biochemical markers of inflammation and endothelial activation. We included men and women (n=352), 20-30 years, screened for normotensive clinic BP (54% white, 40% men). Clinic BP, ambulatory blood pressure monitoring (ABPM), central systolic pressure, aortic pulse wave velocity (aPWV), augmentation index, anthropometry, physical activity and biochemical markers of cardiovascular risk were assessed (lipids, glucose, insulin, markers of endothelial activation and inflammation). Eighteen percent of the study population had MHT (60% white, 68% men). Those with MHT had increased adiposity, clinic-, ABPM- (24-h, day and night) and central-BP (within normal ranges), heart rate, aPWV and biochemical markers of cardiovascular risk, compared with normotensives (all P<0.05). Using multivariable adjusted odds ratios, we found that MHT was associated with increased likelihood for higher aPWV (odds ratio (OR)=1.567, P=0.010), insulin (OR=1.499, P=0.049), monocyte chemoattractant protein-1 (OR=1.499, P=0.026), vascular cellular adhesion molecule (OR=1.409, P=0.042) and C-reactive protein (OR=1.440, P=0.044). In a young adult (supposedly healthy) cohort, the occurrence of MHT is alarming, especially since MHT further demonstrated elevated cardiovascular risk via increased adiposity, arterial stiffness, endothelial activation and inflammation. Detection of MHT is crucial to increase awareness of elevated cardiovascular risk, and to ensure the required lifestyle and/or pharmaceutical interventions.
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