ArticlePloS one2015
Human GAPDH Is a Target of Aspirin's Primary Metabolite Salicylic Acid and Its Derivatives.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Efficacy and safety of licorice (Glycyrrhiza glabra) in moderately ill patients with COVID-19: a randomized controlled trial.Inflammopharmacology · 2023Trial
- Advancing combination treatment with glycyrrhizin and boswellic acids for hospitalized patients with moderate COVID-19 infection: a randomized clinical trial.Inflammopharmacology · 2022Trial
- Article
- Shared and Related Molecular Targets and Actions of Salicylic Acid in Plants and Humans.Cells · 2023Review
- Organelles and phytohormones: a network of interactions in plant stress responses.Journal of experimental botany · 2022Review
- Biobased Ionic Liquids as Multitalented Materials in Lipidic Drug Implants.Pharmaceutics · 2021Article
- Central Metabolism in Mammals and Plants as a Hub for Controlling Cell Fate.Antioxidants & redox signaling · 2021Review
- Proteomic and Phenotypic Analyses of a Putative Glycerol-3-Phosphate Dehydrogenase Required for Virulence inThe plant pathology journal · 2021Article
- Upregulation of IL-1 Receptor Antagonist by Aspirin in Glial Cells via Peroxisome Proliferator-Activated Receptor-Alpha.Journal of Alzheimer's disease reports · 2021Article
- Natural Salicylates and Their Roles in Human Health.International journal of molecular sciences · 2020Review
- Synergistic activation of AMPK prevents from polyglutamine-induced toxicity in Caenorhabditis elegans.Pharmacological research · 2020Article
- Deciphering the Binding of Salicylic Acid toInternational journal of molecular sciences · 2020Article
- Salicylic Acid as a Safe Plant Protector and Growth Regulator.The plant pathology journal · 2020Review
- Action of low doses of Aspirin in Inflammation and Oxidative Stress induced by aβInternational journal of medical sciences · 2020Article
- Aspirin up-regulates suppressor of cytokine signaling 3 in glial cells via PPARα.Journal of neurochemistry · 2019Article
- A genome-wide screen for human salicylic acid (SA)-binding proteins reveals targets through which SA may influence development of various diseases.Scientific reports · 2019Article
- Salicylic Acid Binding Proteins (SABPs): The Hidden Forefront of Salicylic Acid Signalling.International journal of molecular sciences · 2019Review
- How does the multifaceted plant hormone salicylic acid combat disease in plants and are similar mechanisms utilized in humans?BMC biology · 2017Article
- Abscisic Acid as Pathogen Effector and Immune Regulator.Frontiers in plant science · 2017Review
- Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans.PloS one · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The plant hormone salicylic acid (SA) controls several physiological processes and is a key regulator of multiple levels of plant immunity. To decipher the mechanisms through which SA's multiple physiological effects are mediated, particularly in immunity, two high-throughput screens were developed to identify SA-binding proteins (SABPs). Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH) from plants (Arabidopsis thaliana) was identified in these screens. Similar screens and subsequent analyses using SA analogs, in conjunction with either a photoaffinity labeling technique or surface plasmon resonance-based technology, established that human GAPDH (HsGAPDH) also binds SA. In addition to its central role in glycolysis, HsGAPDH participates in several pathological processes, including viral replication and neuronal cell death. The anti-Parkinson's drug deprenyl has been shown to suppress nuclear translocation of HsGAPDH, an early step in cell death and the resulting cell death induced by the DNA alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine. Here, we demonstrate that SA, which is the primary metabolite of aspirin (acetyl SA) and is likely responsible for many of its pharmacological effects, also suppresses nuclear translocation of HsGAPDH and cell death. Analysis of two synthetic SA derivatives and two classes of compounds from the Chinese medicinal herb Glycyrrhiza foetida (licorice), glycyrrhizin and the SA-derivatives amorfrutins, revealed that they not only appear to bind HsGAPDH more tightly than SA, but also exhibit a greater ability to suppress translocation of HsGAPDH to the nucleus and cell death.
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