Evidence map›Paper›PMID 26606115›Full record

ArticlePLoS computational biology2015

VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires.

Mikhail Shugay, Dmitriy V Bagaev, Maria A Turchaninova, Dmitriy A Bolotin, Olga V Britanova, Ekaterina V Putintseva, Mikhail V Pogorelyy, Vadim I Nazarov, Ivan V Zvyagin, Vitalina I Kirgizova and 3 more

Abstract read
In one paragraph

Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 396 papers.

0numbers the graph read from it
0cells of the map it votes in
396citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

396 citing papers in PubMed.

  1. Trial
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  6. T Cell Thoughts.Immunological reviews · 2026
    Review
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336 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mikhail ShugayShemyakin-Ovchinnikov Institute of bioorganic chemistry RAS, Moscow, Russia.
Dmitriy V BagaevShemyakin-Ovchinnikov Institute of bioorganic chemistry RAS, Moscow, Russia.
Maria A TurchaninovaShemyakin-Ovchinnikov Institute of bioorganic chemistry RAS, Moscow, Russia.
Dmitriy A BolotinShemyakin-Ovchinnikov Institute of bioorganic chemistry RAS, Moscow, Russia.
Olga V BritanovaShemyakin-Ovchinnikov Institute of bioorganic chemistry RAS, Moscow, Russia.
Ekaterina V PutintsevaShemyakin-Ovchinnikov Institute of bioorganic chemistry RAS, Moscow, Russia.
Mikhail V PogorelyyShemyakin-Ovchinnikov Institute of bioorganic chemistry RAS, Moscow, Russia.
Vadim I NazarovShemyakin-Ovchinnikov Institute of bioorganic chemistry RAS, Moscow, Russia.
Ivan V ZvyaginShemyakin-Ovchinnikov Institute of bioorganic chemistry RAS, Moscow, Russia.
Vitalina I KirgizovaShemyakin-Ovchinnikov Institute of bioorganic chemistry RAS, Moscow, Russia.
Kirill I KirgizovRussian Children's Hospital, Moscow, Russia.
Elena V SkorobogatovaRussian Children's Hospital, Moscow, Russia.
Dmitriy M ChudakovShemyakin-Ovchinnikov Institute of bioorganic chemistry RAS, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the growing number of immune repertoire sequencing studies, the field still lacks software for analysis and comprehension of this high-dimensional data. Here we report VDJtools, a complementary software suite that solves a wide range of T cell receptor (TCR) repertoires post-analysis tasks, provides a detailed tabular output and publication-ready graphics, and is built on top of a flexible API. Using TCR datasets for a large cohort of unrelated healthy donors, twins, and multiple sclerosis patients we demonstrate that VDJtools greatly facilitates the analysis and leads to sound biological conclusions. VDJtools software and documentation are available at https://github.com/mikessh/vdjtools.

Indexed as

SoftwareAdolescentAdultChildCluster AnalysisComputational BiologyHematopoietic Stem Cell TransplantationHumansMultiple SclerosisReceptors, Antigen, T-CellSequence Analysis, DNATwinsYoung AdultReceptors, Antigen, T-Cell

Identifiers

PMID26606115
PMCPMC4659587

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.